Is CI 21108 safe in cosmetics?
CI 21108 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: prohibited. 3 toxicological study endpoint(s) are available in our database.
CI 21108
Also known as: Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-, Disazo Yellow, Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-, Acetoacetanilide, 2,2''-[(3,3'-dichloro-4,4'-biphenylylene)bis(azo)]bis[4'-chloro-2',5'-dimethoxy-, 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide] (+15 more)
CI 21108 (CAS 5567-15-7) is a cosmetic cosmetic ingredient functioning as Colorant. Reported NOAEL =555 mg/kg bw/day in Mouse (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5567-15-7 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[[2-chloro-4-[3-chloro-4-[[1-(4-chloro-2,5-dimethoxyanilino)-1,3-dioxobutan-2-yl]diazenyl]phenyl]phenyl]diazenyl]-N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide
InChIKey
NKXPXRNUMARIMZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
prohibited
US Notes
Not listed as FDA-certified color additive for cosmetics; not in 21 CFR Part 74 or 82
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 21108.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for CI 21108. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =555 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =702 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1665 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Yellow
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
Product type: Rinse-off products.
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Degradant/impurity
Dye
Pigment
Processing aids not otherwise specified
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 21108.
Regulatory Flags
azo-dye
pigment
diarylide
rinse-off-only
eu-annex-iv-restricted
not-fda-approved
dcb-concern
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 21108 by CAS number or substance name.
Studies
3
Lowest NOAEL
555 mg/kg bw/day
Highest NOAEL
1665 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-
Disazo Yellow
Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-
Acetoacetanilide, 2,2''-[(3,3'-dichloro-4,4'-biphenylylene)bis(azo)]bis[4'-chloro-2',5'-dimethoxy-
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide
Aquafine Yellow E 12
C.I. 21108
Chromofine Yellow 2700(L)
Colanyl Yellow HRD
FG 1842
Graphtol Yellow RCL
HR 70 Yellow
Helio Fast Yellow HRN
Hostafine Yellow HR
Hydrocolor Yellow
Imperial yellow
Imperon Gold Yellow K-RN
Imperon Golden Yellow K-RN
Irgalite Yellow B 3R
Chemical Function
Dye
Pigment
Degradant/impurity
Regulatory Lists
Europe; Personal care
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Europe; plastic_additive
Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 21108 allowed in the EU?
CI 21108 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 21108 do in cosmetics?
CI 21108 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 5567-15-7.
What is the NOAEL for CI 21108?
The NOAEL (No Observed Adverse Effect Level) for CI 21108 is =555 mg/kg bw/day based on a chronic study via oral route in Mouse. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is CI 21108 used outside cosmetics?
CI 21108 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 21108 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
CI 40800 (Beta-Carotene)
Excellent
Same category
Colorant. Synthetic or naturally deri...
CI 75130 (Beta-Carotene)
Excellent
Same category
Colorant. Synthetic or plant-derived ...
CI 75170 (Guanine)
Excellent
Same category
Colorant. Natural crystalline materia...
CI 77004 (Kaolin)
Excellent
Same category
Colorant. Natural white clay mineral ...
CI 77007 (Ultramarine Blue)
Excellent
Same category
Colorant. Inorganic mineral pigment s...
CI 77019 (Mica)
Excellent
Same category
Colorant; Opacifying Agent; Bulking A...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
CI 10006
Moderate
Browse nearby
Colorant (green)
CI 10020
Moderate
Browse nearby
Colorant (green)
CI 10316 (Ext. D&C Yellow No. 7)
Moderate
Browse nearby
Colorant. Synthetic nitro dye (Disodi...
Is CI 21108 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CI 21108 in your formulation.