NOAEL Studies Cosmetic Ingredient

CI 21108 NOAEL Studies

CAS: 5567-15-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >0.23 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=843; Record_ID=acute_inhalation_2410; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021453; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.23; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16028/7/3/3/?documentUUID=6e3e6173-bf34-4402-bfe3-18a70697e57c; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021453
NTP_ICE_acute_inhalation LC50 >4.25 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=844; Record_ID=acute_inhalation_2408; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021453; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.25; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16028/7/3/3/?documentUUID=07b282c3-71b8-4335-9fb2-31069d600a6a; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021453
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =555 mg/kg bw/day Mouse oral chronic; 104 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaebde4b0a7c65d1cabee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10976/7/6/2?documentUUID=2afdcf58-76b3-41e0-bd26-1da5c549cae5; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832598_15832740_15833126_15834633_15841912_15843747_15844000_15844243_15845592_15846161_15850915_15850933_15850967_15850972_15851000:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_68d25e9a5853314a4560f594f72bcc43
ToxValDB_ECHA_IUCLID NOAEL =702 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3bb7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2023/7/8?documentUUID=542e7187-04a0-4ac3-80fb-f10bdd3d414d; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820401_15820402_15820403_15820404_15820405_15820406_15820407_15820408_15820409_15820410:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a79e183dff605c1de7d961d61203a2a
ToxValDB_ECHA_IUCLID NOAEL =1665 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11673/7/8?documentUUID=88b8eb08-e64e-4afd-872d-de733b239107; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820415_15820416_15820417_15820418_15820419_15820420_15820421_15820422_15820423_15820424:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_41feee9215d700d40b24c3528401b681
ToxValDB_EPA_TSCA_8e 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LEL =10 mg/m3 Rat inhalation short-term; 5 days short-term GUIDELINE=OECD 412; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21530_11.5.2018_Combined.pdf; TOXICOLOGICAL_EFFECT=neutrophil infiltrate in bronchiolar epithelium; STUDY_GROUP=EPA TSCA 8e_dup_-_15957473_15957474:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f0de184b14f8e90e3affd36026273260
ToxValDB_EPA_TSCA_8e LEL =30 mg/m3 Rat inhalation short-term; 5 days short-term GUIDELINE=OECD 412; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21530_11.5.2018_Combined.pdf; TOXICOLOGICAL_EFFECT=changes in blood cell counts in bronchioalveolar lavage, neutrophil infiltrate in bronchiolar epithelium; STUDY_GROUP=EPA TSCA 8e_dup_-_15957473_15957474:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a2fc5b962e3070d86dc37ded44e64c7
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =630 mg/kg bw/day Rat oral chronic; 104 weeks chronic LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 28th June, 2006.Reference:Leuschner, F., Carcinogenicity Studies of Different Diarylide Yellow Pigments in Mice and Rats, Toxocol. Lett. 2,253-260, (1978), C.I. Pigment Yellow 83.See also, Longstaff, E., An Assessment and Categorization of the Animal Carcinogenicity Data on Selelcted Dyestuffs and an Extrapolation of Those Data to an Evaluation of the Relative Carcinogenic Risk to Man, Dyes and Pigments 4,243-304, 1983. See also Decad, G. M. et al. Fate of Water - Insoluble and Water Soluble Dichlorobenzidine - Based Pigments in Fischer 344 Rats, Journal of Toxicology and Environmental Health, Vol. 11, pp. 455-465, 1983. (Radio labeled study of C.I. Pigment Yellow 12 indicating no detectable pigment in any tissue at points up to one day.); QUALITY=2; EXTERNAL_SOURCE_ID=60950; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=HPVIS:15639122:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_28fb53688f2d66af175c973ed42aaca4
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 67HO7X7FV3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H32Cl4N6O8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67HO7X7FV3"}
openFDA substances FDA UNII substance identifier 67HO7X7FV3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H32Cl4N6O8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67HO7X7FV3"}
openFDA substances FDA UNII substance identifier 67HO7X7FV3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H32Cl4N6O8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67HO7X7FV3"}
openFDA substances FDA UNII substance identifier 67HO7X7FV3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H32Cl4N6O8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67HO7X7FV3"}