Is Chelidonine safe in cosmetics?
Chelidonine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Chelidonine
INCI: CHELIDONINE
Chelidonine (CAS 476-32-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (isolated alkaloid from Chelidonium majus). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 476-32-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Chelidonine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning agent (isolated alkaloid from Chelidonium majus)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
(1S,12S,13R)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol
InChIKey
GHKISGDRQRSCII-ZOCIIQOWSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No CIR review; no specific FDA monograph; manufacturer bears full burden of safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chelidonine.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Chelidonine.
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHELIDONINE
ChEMBL ID
CHEMBL496867
Frequently Asked Questions
Is Chelidonine allowed in the EU?
Chelidonine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Chelidonine do in cosmetics?
Chelidonine functions as: Skin conditioning agent (isolated alkaloid from Chelidonium majus). It is classified as a cosmetic ingredient in our database. CAS number: 476-32-4.
Is Chelidonine used outside cosmetics?
Chelidonine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Chelidonine have different safety status in cosmetics vs industrial chemicals?
Chelidonine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332).
Compliance Tools
Check Chelidonine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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CHELIDONIUM MAJUS EXTRACT
Good
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Anti-seborrheic
CHITOSAN ASCORBATE
Good
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CHITOSAN GLYCOLATE
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