Also known as: 1-Cetanol, 1-Hydroxyhexadecane, Lorol 24, Hexadecyl alcohol, C16 alcohol (+15 more)
INCI: CETYL ALCOHOL
Cetyl Alcohol (CAS 36653-82-4) is a cosmetic emollient functioning as emollient, emulsion stabilizer. Reported NOAEL =1822 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 36653-82-4 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Cetyl Alcohol.
Calculate MoS for your specific formulation with the MoS Calculator.
2 study endpoints found for Cetyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1822 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =4567 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Contact sensitization data for Cetyl Alcohol based on clinical patch test studies and IFRA standards.
Source: IVDK; ESSCA; NACDG
Skin absorption and penetration characteristics of Cetyl Alcohol, relevant to systemic exposure and MoS calculations.
Source: CIR
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | >1000 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | >=1198 mg/kg-day | Dog | oral | subchronic | ECHA IUCLID |
| NOAEL | >=1053 mg/kg-day | Dog | oral | subchronic | ECHA IUCLID |
| NOAEL | =4567 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| LD50 | >7960 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | >1000 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | =1822 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =4567 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | >1000 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | =4567 mg/kg-day | Rat | oral | - | ECHA IUCLID |
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 1–4 | 10 | CIR/VCRP |
| Body Lotion | 1–4 | 10 | CIR/VCRP |
| Conditioner | 2–5 | 10 | CIR/VCRP |
10 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Cetyl Alcohol.
Public NOAEL study rows linked to Cetyl Alcohol by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Cetyl Alcohol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Cetyl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Cetyl Alcohol functions as: emollient, emulsion stabilizer. It is classified as a Emollient in our database. CAS number: 36653-82-4.
The NOAEL (No Observed Adverse Effect Level) for Cetyl Alcohol is =1822 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Cetyl Alcohol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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