NOAEL Studies
Emollient
Cetyl Alcohol NOAEL Studies
INCI: CETYL ALCOHOL
CAS: 36653-82-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >21 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2466; Record_ID=acute_inhalation_670; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=21; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15942/7/3/3/?documentUUID=da766640-25dc-49c8-a5a4-d524042a8375; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
| NTP_ICE_acute_inhalation | LC50 | >71 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2467; Record_ID=acute_inhalation_676; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=71; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15942/7/3/3/?documentUUID=6bb152c2-2abd-49db-8985-92528ca7f3ec; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
| NTP_ICE_acute_inhalation | LC50 | >2.05 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2468; Record_ID=acute_inhalation_689; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.05; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15942/7/3/3/?documentUUID=5e5fe519-1a20-4132-8bfe-e4208b3a5a95; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
| NTP_ICE_acute_inhalation | LC50 | >0.7 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2469; Record_ID=acute_inhalation_657; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.7; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15942/7/3/3/?documentUUID=38731d5a-6d2d-4486-a6b0-6df1a88a338f; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
| NTP_ICE_acute_inhalation | LC50 | >1.5 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2470; Record_ID=acute_inhalation_667; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.5; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15942/7/3/3/?documentUUID=ec180380-3fd1-46b0-b68a-b863d8848b3e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1132; RecordID=ARPathway2016_1171; DatasetName=ARPathway2016; DTXSID=DTXSID4027991; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6966; Record_ID=skin_sensitization_invivo_1592; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80072-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 8100 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6964; Record_ID=skin_sensitization_invivo_1592; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=8100; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80072-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6970; Record_ID=skin_sensitization_invivo_1592; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4027991; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80072-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027991 |
ToxValDB_ECHA_IUCLID 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | >1000 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1223; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/6/2?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847274_15847383_15847393_15848501:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0fc00caca26b2bab9ce9268f721ee1c4 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=1198 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c121f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/6/2?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850408_15850409:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f125ef0a4459776a3d4c1c6ad58c3d2 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=1053 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c121f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/6/2?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850410_15850411:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0950f2f035ebc987d7c9673ea19fed10 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1822 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5a11; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2096/7/9/2?documentUUID=e731448f-4c87-4e5e-aa4f-90b6daeffd79; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15861249:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4b7c860fcf8bb72509c55c8f3e93931d |
| ToxValDB_ECHA_IUCLID | NOAEL | =4567 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5a11; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2096/7/9/2?documentUUID=e731448f-4c87-4e5e-aa4f-90b6daeffd79; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15861260:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7c83d3f3896f32b987967260f018fb18 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =200 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632458_15632459:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23d9bdbfa697c6906f4f534ceb6cd8f3 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =389 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632458_15632459:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a8e3b8d6482211545b06a99451152e3a |
ToxValDB_HESS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOAEL | =723 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb79; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Food Consumption: decrease |Relative Organ Weight: Brain increase; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|organ weight; STUDY_GROUP=HESS:15638815:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_db436a8a7ad29bf4cb68d41cf0787b15 |
| ToxValDB_HESS | NOAEL | =875 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb79; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=body weight decrease|food consumption decrease|Absolute organ weight: brain|relative organ weight: brain increase|relative organ weight: liver increase (males); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=HESS:15638925:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_10925152b215ed0214ece9834fc633cc |
| ToxValDB_HESS | NOEL | =100 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Thinly haired areas of skin Weakness Thin appearance Respiratory disorders Some resistance to dosing|Body Weight Changes: decrease|Food Consumption: decrease|Hematology: Plt decrease, MONO decrease, MCH decrease300 |Blood Chemistry: ALP increase, Cho increase, A/G increase|Relative Organ Weight: Kidney increase; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|organ weight; STUDY_GROUP=HESS:15638814:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8473664df6aa41fd101af58c5f2822b6 |
| ToxValDB_HESS | NOEL | =300 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Thinly haired areas of skin Weakness Thin appearance Respiratory disorders Some resistance to dosing|Body Weight Changes: decrease|Food Consumption: decrease|Hematology: Plt decrease, MONO decrease, MCH decrease300 |Blood Chemistry: ALP increase, Cho increase, A/G increase|Relative Organ Weight: Kidney increase; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|organ weight; STUDY_GROUP=HESS_dup_-_15638923_15638924:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f352bc8181311f4b33c7791a8608353a |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 936JST6JCN | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H34O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"936JST6JCN"} |
| openFDA substances | FDA UNII substance identifier | 936JST6JCN | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H34O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"936JST6JCN"} |
| openFDA substances | FDA UNII substance identifier | 936JST6JCN | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H34O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"936JST6JCN"} |
| openFDA substances | FDA UNII substance identifier | 936JST6JCN | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H34O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"936JST6JCN"} |