What is the NOAEL for 1-Hexadecanol?
1-Hexadecanol has 24 NOAEL studies in the database. The lowest reported value is 200 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Hexadecanol
Also known as: 1-Cetanol, 1-Hydroxyhexadecane, Lorol 24, Hexadecyl alcohol, C16 alcohol (+15 more)
CAS 36653-82-4
1-Hexadecanol (CAS 36653-82-4) is a chemical substance. Key regulatory status: REACH registered, 22 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
24
SOURCE
chemical inventory jurisdictions
Regulatory lists
22
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
1-Hexadecanol
CAS Number
36653-82-4
DTXSID
DTXSID4027991
Molecular Formula
C16H34O
InChI Key
BXWNKGSJHAJOGX-UHFFFAOYSA-N
Monoisotopic Mass
242.260966
Synonyms
1-Cetanol1-HydroxyhexadecaneLorol 24Hexadecyl alcoholC16 alcohol4-01-00-01876BRN 1748475Caswell No. 165DEINECS 253-149-0EPA Pesticide Chemical Code 001508Fatty alcohol(C16)FEMA No. 2554
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Thickening agentSurfactant (surface active agent)Softener and conditionerDeodorizerEmulsifierViscosity modifierOpaciferFoamantSolventStabilizing agentFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
22 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe | European Commission | Fl@vis |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =200 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =389 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 936JST6JCN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 936JST6JCN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 936JST6JCN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 936JST6JCN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >0.7 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >1.5 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2.05 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >21 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >71 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =723 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =875 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1053 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| >=1198 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =1822 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =4567 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| =300 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexadecan-1-ol | 253-149-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CETYL ALCOHOL
ChEMBL Phase
4
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-Hexadecanol?
1-Hexadecanol appears on 16 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, consumer_product, and 13 more. Source: EPA CPDat.
Is 1-Hexadecanol used in cosmetics?
Yes, 1-Hexadecanol is also indexed as a cosmetic ingredient under the name Cetyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Hexadecanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1-Hexadecanol used outside industrial chemicals?
1-Hexadecanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.