Is Ceramide NS safe in cosmetics?
Ceramide NS has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
Ceramide NS
Also known as: Ceramides, N-Acylsphingosine, N-Acylsphingosines, Synthetic ceramide, Synthetic ceramides (+1 more)
INCI: CERAMIDE NS
Ceramide NS (CAS 100403-19-8) is a cosmetic active ingredient functioning as Ceramide 2 (N-stearoyl sphingosine). Non-hydroxy fatty acid sphingosine. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 100403-19-8 →
Auto-generated CPSR Part A draft with source citations
Function
Ceramide 2 (N-stearoyl sphingosine). Non-hydroxy fatty acid sphingosine ceramide. Lamellar lipid component providing structural rigidity and water barrier function in stratum corneum. Works synergistically with ceramides NP, AP, and EOP in triple-lipid system.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted without restriction. Part of multi-ceramide longevity skincare formulations. Most effective in combination with ceramides NP, AP, EOP, cholesterol, and free fatty acids. MoCRA safety substantiation required.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ceramide NS.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
acne
{"cas_number": "100403-19-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "104404-17-3", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "3.0", "typical_concentration_pct": "1.0", "product_type": "Moisturizer", "function_at_concentration": "Barrier repair", "source": "Supplier TDS"}
hair_care
{"hair_function": "strengthening", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "balanced", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthens"…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Regulatory List Membership (2)
EU Regulated in Personal Care
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Ceramide NS.
Regulatory Flags
ceramide
barrier-function
longevity-skincare
skin-identical
evidence-backed
anti-aging
Known Synonyms
Ceramides
N-Acylsphingosine
N-Acylsphingosines
Synthetic ceramide
Synthetic ceramides
EC No.: 309-560-3
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Europe; Personal care
Europe; Personal care
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is Ceramide NS allowed in the EU?
Ceramide NS EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ceramide NS do in cosmetics?
Ceramide NS functions as: Ceramide 2 (N-stearoyl sphingosine). Non-hydroxy fatty acid sphingosine ceramide. Lamellar lipid component providing structural rigidity and water barrier function in stratum corneum. Works synergistically with ceramides NP, AP, and EOP in triple-lipid system.. It is classified as a Active Ingredient in our database. CAS number: 100403-19-8.
Compliance Tools
Check Ceramide NS compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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