Is Ceramide 2 safe in cosmetics?
Ceramide 2 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Ceramide 2
Also known as: Ceramides, N-Acylsphingosine, N-Acylsphingosines, Synthetic ceramide, Synthetic ceramides (+1 more)
INCI: CERAMIDE NS
Ceramide 2 (CAS 100403-19-8) is a cosmetic cosmetic ingredient functioning as Hair conditioning, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 100403-19-8 →
Auto-generated CPSR Part A draft with source citations
Function
Hair conditioning, skin conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Reported in VCRP; used at concentrations up to 4%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ceramide 2.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
acne
{"cas_number": "100403-19-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "104404-17-3", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "3.0", "typical_concentration_pct": "1.0", "product_type": "Moisturizer", "function_at_concentration": "Barrier repair", "source": "Supplier TDS"}
hair_care
{"hair_function": "strengthening", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "balanced", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthens"…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Regulatory List Membership (2)
EU Regulated in Personal Care
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Ceramide 2.
Regulatory Flags
potential-allergen
Known Synonyms
Ceramides
N-Acylsphingosine
N-Acylsphingosines
Synthetic ceramide
Synthetic ceramides
EC No.: 309-560-3
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Europe; Personal care
Europe; Personal care
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is Ceramide 2 allowed in the EU?
Ceramide 2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ceramide 2 do in cosmetics?
Ceramide 2 functions as: Hair conditioning, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 100403-19-8.
Compliance Tools
Check Ceramide 2 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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