Is Cayenne Pepper Extract safe in cosmetics?
Cayenne Pepper Extract has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Cayenne Pepper Extract
INCI: CAPSICUM ANNUUM FRUIT EXTRACT
Cayenne Pepper Extract (CAS 84625-29-6) is a cosmetic cosmetic ingredient functioning as Warming agent, counterirritant; capsaicin TRPV1 agonist. Reported NOAEL =2052 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84625-29-6 →
Auto-generated CPSR Part A draft with source citations
Function
Warming agent, counterirritant; capsaicin TRPV1 agonist
Safety Rating
MODERATE
Chemistry & Identifiers
EC Number
283-403-6
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA: capsaicin OTC analgesic monograph at 0.025-0.25%.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cayenne Pepper Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Cayenne Pepper Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2052 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =2324 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =2388 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =2948.4 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =3197.4 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-dandruff
Antioxidant
Astringent
Biocide
Humectant
No specific technical function
Softener and conditioner
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Cayenne Pepper Extract.
Regulatory Flags
eu_children_restricted
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cayenne Pepper Extract by CAS number or substance name.
Studies
5
Lowest NOAEL
2052 mg/kg bw/day
Highest NOAEL
3197.4 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Biocide
Antioxidant
Humectant
Astringent
Deodorizer
Softener and conditioner
Regulatory Lists
children
Europe
Personal care
children
Europe
Personal care - dental care - toothpaste
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cayenne Pepper Extract allowed in the EU?
Cayenne Pepper Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cayenne Pepper Extract do in cosmetics?
Cayenne Pepper Extract functions as: Warming agent, counterirritant; capsaicin TRPV1 agonist. It is classified as a cosmetic ingredient in our database. CAS number: 84625-29-6.
What is the NOAEL for Cayenne Pepper Extract?
The NOAEL (No Observed Adverse Effect Level) for Cayenne Pepper Extract is =2052 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 5 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Cayenne Pepper Extract used outside cosmetics?
Cayenne Pepper Extract also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cayenne Pepper Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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