Is Capryloyl Glycine safe in cosmetics?
Capryloyl Glycine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Capryloyl Glycine
Also known as: EINECS 238-122-3, UNII-8TY5YO42NJ, 2-octanamidoacetic acid, Caprylylglycine, N-(1-Oxooctyl)glycine (+1 more)
INCI: CAPRYLOYL GLYCINE
Capryloyl Glycine (CAS 14246-53-8) is a cosmetic cosmetic ingredient functioning as Cleansing, emollient, hair conditioning, skin conditioning, surfactant,. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 14246-53-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Capryloyl Glycine is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Cleansing, emollient, hair conditioning, skin conditioning, surfactant, antiseborrheic, antiseptic, deodorant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(octanoylamino)acetic acid
InChIKey
SAVLIIGUQOSOEP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Generally considered safe; low skin irritation potential
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Capryloyl Glycine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Capryloyl Glycine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Capryloyl Glycine across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
acne
{"cas_number": "14246-53-8", "anti_acne_mechanism": "sebum_regulation/antibacterial", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "non_inflammatory", "p_acnes_mic_ug_per_ml": ">500", "sebum_reduction_pct_clinical": "15-25", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_funct…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Softener and conditioner
Surfactant (surface active agent)
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Capryloyl Glycine.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Capryloyl Glycine by CAS number or substance name.
Studies
1
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 238-122-3
UNII-8TY5YO42NJ
2-octanamidoacetic acid
Caprylylglycine
N-(1-Oxooctyl)glycine
capryloylglycine
Chemical Function
Surfactant (surface active agent)
Cleaning agent
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care
Europe; Personal care
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Capryloyl Glycine allowed in the EU?
Capryloyl Glycine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Capryloyl Glycine do in cosmetics?
Capryloyl Glycine functions as: Cleansing, emollient, hair conditioning, skin conditioning, surfactant, antiseborrheic, antiseptic, deodorant. It is classified as a cosmetic ingredient in our database. CAS number: 14246-53-8.
What is the NOAEL for Capryloyl Glycine?
The NOAEL (No Observed Adverse Effect Level) for Capryloyl Glycine is =200 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Capryloyl Glycine used outside cosmetics?
Capryloyl Glycine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Capryloyl Glycine have different safety status in cosmetics vs industrial chemicals?
Capryloyl Glycine is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Capryloyl Glycine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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