What is the NOAEL for Glycine, N-(1-oxooctyl)-?
Glycine, N-(1-oxooctyl)- has 8 NOAEL studies in the database. The lowest reported value is 1.57 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Glycine, N-(1-oxooctyl)-
Also known as: EINECS 238-122-3, UNII-8TY5YO42NJ, 2-octanamidoacetic acid, Caprylylglycine, N-(1-Oxooctyl)glycine (+1 more)
CAS 14246-53-8
Glycine, N-(1-oxooctyl)- (CAS 14246-53-8) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Glycine, N-(1-oxooctyl)- is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Glycine, N-(1-oxooctyl)-
CAS Number
14246-53-8
DTXSID
DTXSID9065736
Molecular Formula
C10H19NO3
InChI Key
SAVLIIGUQOSOEP-UHFFFAOYSA-N
Monoisotopic Mass
201.136493
Synonyms
EINECS 238-122-3UNII-8TY5YO42NJ2-octanamidoacetic acidCaprylylglycineN-(1-Oxooctyl)glycinecapryloylglycine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
10 records
Surfactant (surface active agent)Cleaning agentSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.57 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8TY5YO42NJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8TY5YO42NJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8TY5YO42NJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8TY5YO42NJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| >2500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N-(1-oxooctyl)glycine | 238-122-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Frequently Asked Questions
What regulatory lists include Glycine, N-(1-oxooctyl)-?
Glycine, N-(1-oxooctyl)- appears on 2 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care. Source: EPA CPDat.
Is Glycine, N-(1-oxooctyl)- used in cosmetics?
Yes, Glycine, N-(1-oxooctyl)- is also indexed as a cosmetic ingredient under the name Capryloyl Glycine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glycine, N-(1-oxooctyl)- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Glycine, N-(1-oxooctyl)- have different safety status in cosmetics vs industrial chemicals?
Glycine, N-(1-oxooctyl)- is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is Glycine, N-(1-oxooctyl)- used outside industrial chemicals?
Glycine, N-(1-oxooctyl)- also appears in cosmetics databases.