Is Cannabidiol (CBD) safe in cosmetics?
Cannabidiol (CBD) has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 10 toxicological study endpoint(s) are available in our database.
Cannabidiol (CBD)
Also known as: 1,3-Benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, 1,3-Benzenediol, 2-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, (1R-trans)-, 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3- benzenediol, (-)-Cannabidiol, Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)- (+7 more)
INCI: CANNABIDIOL
Cannabidiol (CBD) (CAS 13956-29-1) is a cosmetic cosmetic ingredient functioning as Insufficient data available. Reported NOAEL =80 mg/kg bw/day in rabbit (New Zealand White; male/female) (FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z); EU Regulation 1223/2009 status: permitted, max 0.19%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 13956-29-1 →
Auto-generated CPSR Part A draft with source citations
Function
Insufficient data available
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.19%
US US Status
restricted
US Notes
Classified as OTC drug; no specific cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cannabidiol (CBD).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Cannabidiol (CBD). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =80 mg/kg bw/day | oral: gavage | rabbit (New Zealand White; male/female) | developmental toxicity teratogenicity | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =80 mg/kg bw/day | oral: gavage | rabbit (New Zealand White; male/female) | developmental toxicity teratogenicity | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =80 mg/kg bw/day | oral: gavage | rabbit (New Zealand White; male/female) | developmental toxicity teratogenicity | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =80 mg/kg bw/day | oral: gavage | rabbit (New Zealand White; male/female) | developmental toxicity teratogenicity | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =400 mg/kg bw/day | oral: gavage | mouse (CD-1; male) | repeated dose toxicity oral | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =400 mg/kg bw/day | oral: gavage | mouse (CD-1; male) | repeated dose toxicity oral | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =400 mg/kg bw/day | oral: gavage | mouse (CD-1; male) | repeated dose toxicity oral | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =400 mg/kg bw/day | oral: gavage | mouse (CD-1; male) | repeated dose toxicity oral | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =550 mg/kg bw/day | oral: gavage | mouse (CD-1; female) | repeated dose toxicity oral | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
| NOAEL | =550 mg/kg bw/day | oral: gavage | mouse (CD-1; female) | repeated dose toxicity oral | FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Korea (Prohibited): Must not be used
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Pharmaceutical
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Cannabidiol (CBD).
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cannabidiol (CBD) by CAS number or substance name.
Studies
96
Lowest NOAEL
9
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/day, mg/kg/day, mg/kg
FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z
SCCS_vision_codex
Known Synonyms
1,3-Benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-
1,3-Benzenediol, 2-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, (1R-trans)-
2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3- benzenediol
(-)-Cannabidiol
Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)-
(-)-trans-Cannabidiol
Δ1(2)-trans-Cannabidiol
CERAPP_63267
(-)-CBD
CBD
Epidiolex
GWP 42003P
Chemical Function
Antioxidant
Humectant
Softener and conditioner
Pharmaceutical
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CANNABIDIOL
ChEMBL ID
CHEMBL190461
Max Phase
4
Adverse Event Associations
1179
Frequently Asked Questions
Is Cannabidiol (CBD) allowed in the EU?
Cannabidiol (CBD) EU regulatory status: permitted. Maximum allowed concentration: 0.19%. This is based on EU Regulation 1223/2009 and its amendments.
What does Cannabidiol (CBD) do in cosmetics?
Cannabidiol (CBD) functions as: Insufficient data available. It is classified as a cosmetic ingredient in our database. CAS number: 13956-29-1.
What is the NOAEL for Cannabidiol (CBD)?
The NOAEL (No Observed Adverse Effect Level) for Cannabidiol (CBD) is =80 mg/kg bw/day based on a developmental toxicity teratogenicity study via oral: gavage route in rabbit (New Zealand White; male/female). A total of 10 study endpoints are available. Source: FDA_Toxicity_33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z.
Is Cannabidiol (CBD) used outside cosmetics?
Cannabidiol (CBD) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cannabidiol (CBD) compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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