Is Calcium Pantothenate safe in cosmetics?
Calcium Pantothenate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
Calcium Pantothenate
Also known as: beta-Alanine, N-((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1), EC No.: 205-278-9, Calpan, D-Pantothenic acid hemicalcium salt (+15 more)
INCI: CALCIUM PANTOTHENATE
Calcium Pantothenate (CAS 137-08-6) is a cosmetic active ingredient functioning as Provitamin B5 (pantothenic acid) calcium salt; barrier repair active;. EU Regulation 1223/2009 status: permitted, max 0.5–2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 137-08-6 →
Auto-generated CPSR Part A draft with source citations
Function
Provitamin B5 (pantothenic acid) calcium salt; barrier repair active; skin-conditioning; supports keratinocyte differentiation via calcium gradient signaling; humectant; promotes wound healing and skin elasticity
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
calcium bis(3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate)
InChIKey
FAPWYRCQGJNNSJ-UBKPKTQASA-L
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.5–2%
US US Status
permitted
US Notes
No FDA restriction; used as cosmetic and OTC drug ingredient (wound-healing, skin-conditioning). CIR has not identified safety concerns at cosmetic concentrations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Pantothenate.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =10000 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >10000 mg/kg | Rat | oral | - | ChemIDplus |
Additional Ingredient Properties
5 property records from structured ingredient metadata.
acne
{"cas_number": "137-08-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory/non_inflammatory", "sebum_reduction_pct_clinical": "5-15", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosm…
anti_aging
{"anti_aging_claim": "hydration-plumping, barrier-repair", "mechanism_of_action": "Cofactor for enzymatic reactions, antioxidant activity", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "4-8", "clinical_study_duration_weeks": "12", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": …
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "5.0", "typical_concentration_pct": "2.0", "product_type": "Serum", "function_at_concentration": "Hydration, barrier repair", "source": "CIR Safety Assessment"}
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "no", "soluble_in": "water, glycerin, propylene glycol", "insoluble_in": "oils, ethanol, silicones", "log_p": "-2.8", "melting_point_c": "170-172", "appearance": "white powder", "source": "BASF"}
vitamin
{"cas_number": "137-08-6", "ingredient_class": "vitamin_B5", "chemical_form": "salt", "derivative_type": "stabilized", "molecular_weight_Da": "476.54", "water_solubility": "soluble", "oil_solubility": "insoluble", "log_P": "-1.50", "stability_to_light": "excellent", "stability_to_heat": "excellent", "stability_to_oxidation": "excellent", "stability_to_pH_acid": "excellent", "stability_to_pH_alkali…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Pharmaceutical
Softener and conditioner
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Pantothenate.
Regulatory Flags
provitamin-b5
barrier-repair
keratinocyte-support
calcium-gradient
skin-conditioning
wound-healing
hair-care
gentle
well-tolerated
epa_safer_alternative
fda_food_additive
Known Synonyms
beta-Alanine, N-((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1)
.beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1)
EC No.: 205-278-9
Calpan
D-Pantothenic acid hemicalcium salt
Pancal
Panthothenic acid hemicalcium salt
calcium pantothenate , D-form
N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine calcium salt (2:1)
Bis(pantothenato)calcium
Ca-HOPA
Calcium D(+)-N-(alpha,gamma-dihydroxy-beta,beta-dimethylbutyryl)-beta-alaninate
Calcium N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine (1:2), (R)-
Calcium panthothenate
Calcium pantothenate (2:1)
D-Calcium pantothenate calcium chloride double salt
Cris Pan
N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine calcium
EINECS 205-278-9
Pantothenic acid, calcium salt
Chemical Function
Anti-static agent
Softener and conditioner
Pharmaceutical
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Calcium Pantothenate allowed in the EU?
Calcium Pantothenate EU regulatory status: permitted. Maximum allowed concentration: 0.5–2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Pantothenate do in cosmetics?
Calcium Pantothenate functions as: Provitamin B5 (pantothenic acid) calcium salt; barrier repair active; skin-conditioning; supports keratinocyte differentiation via calcium gradient signaling; humectant; promotes wound healing and skin elasticity. It is classified as a Active Ingredient in our database. CAS number: 137-08-6.
Is Calcium Pantothenate used outside cosmetics?
Calcium Pantothenate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Pantothenate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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