What is the NOAEL for Calcium pantothenate?
Calcium pantothenate has 9 NOAEL studies in the database. The lowest reported value is 568ET80C3D UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Calcium pantothenate
Also known as: beta-Alanine, N-((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1), EC No.: 205-278-9, Calpan, D-Pantothenic acid hemicalcium salt (+15 more)
CAS 137-08-6
Calcium pantothenate (CAS 137-08-6) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Calcium pantothenate
CAS Number
137-08-6
DTXSID
DTXSID8040438
Molecular Formula
2C9H17NO5.Ca
InChI Key
FAPWYRCQGJNNSJ-UBKPKTQASA-L
Monoisotopic Mass
478.183936
Synonyms
beta-Alanine, N-((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1).beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1)EC No.: 205-278-9CalpanD-Pantothenic acid hemicalcium saltPancalPanthothenic acid hemicalcium saltcalcium pantothenate , D-formN-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine calcium salt (2:1)Bis(pantothenato)calciumCa-HOPACalcium D(+)-N-(alpha,gamma-dihydroxy-beta,beta-dimethylbutyryl)-beta-alaninate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
14 records
Anti-static agentSoftener and conditionerPharmaceuticalFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 568ET80C3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 568ET80C3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 568ET80C3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 568ET80C3D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 20 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 400 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 9 of 9 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.5–2%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CALCIUM PANTOTHENATE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Calcium pantothenate?
Calcium pantothenate appears on 6 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, pharmaceutical, and 3 more. Source: EPA CPDat.
Is Calcium pantothenate used in cosmetics?
Yes, Calcium pantothenate is also indexed as a cosmetic ingredient under the name Calcium Pantothenate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium pantothenate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Calcium pantothenate used outside industrial chemicals?
Calcium pantothenate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.