Is Calcium Hydroxymethionine safe in cosmetics?
Calcium Hydroxymethionine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Calcium Hydroxymethionine
Also known as: Calcium bis((1)-2-hydroxy-4-(methylthio)butyrate), Butanoic acid, 2-hydroxy-4-(methylthio)-, calcium salt (2:1), Calcium DL-2-hydroxy-4-methylthiobutyrate, Calcium DL-alpha-hydroxy-gamma-methylthiobutyrate, Calcium alpha-hydroxy-gamma-methylmercaptobutyrate (+8 more)
INCI: CALCIUM HYDROXYMETHIONINE
Calcium Hydroxymethionine (CAS 4857-44-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning (calcium salt of. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 4857-44-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, hair conditioning (calcium salt of 2-hydroxy-4-(methylthio)butanoic acid)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
calcium bis(2-hydroxy-4-methylsulfanylbutanoate)
InChIKey
ABRVDWASZFDIEH-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Insufficient cosmetic-specific data to calculate MoS; EFSA oral ADI data available but dermal extrapolation needed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Hydroxymethionine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Hydroxymethionine.
Known Synonyms
Calcium bis((1)-2-hydroxy-4-(methylthio)butyrate)
Butanoic acid, 2-hydroxy-4-(methylthio)-, calcium salt (2:1)
Calcium DL-2-hydroxy-4-methylthiobutyrate
Calcium DL-alpha-hydroxy-gamma-methylthiobutyrate
Calcium alpha-hydroxy-gamma-methylmercaptobutyrate
D-L-alpha-Hydroxylmethionine calcium
DL-Methioninehydroxyanalog calcium
Methionine hydroxyl analog calcium salt
2-Hydroxy-4-(methylthio)butyric acid calcium salt
Hydan
Hydan (methionine hydroxy analog)
MHA
MHA-84
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Calcium Hydroxymethionine allowed in the EU?
Calcium Hydroxymethionine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Hydroxymethionine do in cosmetics?
Calcium Hydroxymethionine functions as: Skin conditioning, hair conditioning (calcium salt of 2-hydroxy-4-(methylthio)butanoic acid). It is classified as a cosmetic ingredient in our database. CAS number: 4857-44-7.
Is Calcium Hydroxymethionine used outside cosmetics?
Calcium Hydroxymethionine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Hydroxymethionine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Same category
Skin conditioning (skin brightening/l...
4-Amino-3-Hydroxybutyric Acid
Excellent
Same category
Skin Conditioning
Acetyl Glycyl Beta-Alanine
Excellent
Same category
Skin conditioning agent with melanin ...
Acetyl Tripeptide-1
Excellent
Same category
Skin Conditioning
Acetylneuraminic Acid
Excellent
Same category
Skin Conditioning, Skin Protecting
Acetylphytosphingosine
Excellent
Same category
Skin Conditioning, Hair Conditioning;...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
1,2,3,4,4a,7,8,8a-Octahydro-2,4a,5,8a-Tetramethyl-Naphthyl Formate
Moderate
Similar safety
Fragrance ingredient
CI 42100 (Acid Green 9 / Steel Blue)
Moderate
Chemical family
Colorant. Synthetic triphenylmethane ...
CALCIUM ASCORBATE
Good
Browse nearby
Antioxidant, Skin Conditioning
CALCIUM BEHENATE
Good
Browse nearby
Anticaking, Opacifying, Viscosity Con...
Is Calcium Hydroxymethionine in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Calcium Hydroxymethionine in your formulation.