Is Butyl Glycolate safe in cosmetics?
Butyl Glycolate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Butyl Glycolate
Also known as: Acetic acid, hydroxy-, butyl ester, EINECS 230-991-7, Polysolvan 0
INCI: BUTYL GLYCOLATE
Butyl Glycolate (CAS 7397-62-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning. Reported NOAEL =100 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7397-62-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Butyl Glycolate is classified GHS Danger (H318, H227, H319, H361) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
butyl 2-hydroxyacetate
InChIKey
VFGRALUHHHDIQI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Adequate at ≤30% and pH ≥3.0 per CIR parameters
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Glycolate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Butyl Glycolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Glycolate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butyl Glycolate by CAS number or substance name.
Studies
2
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Acetic acid, hydroxy-, butyl ester
EINECS 230-991-7
Polysolvan 0
Chemical Function
Softener and conditioner
Solvent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184386
Frequently Asked Questions
Is Butyl Glycolate allowed in the EU?
Butyl Glycolate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Glycolate do in cosmetics?
Butyl Glycolate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 7397-62-8.
What is the NOAEL for Butyl Glycolate?
The NOAEL (No Observed Adverse Effect Level) for Butyl Glycolate is =100 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Butyl Glycolate used outside cosmetics?
Butyl Glycolate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Butyl Glycolate have different safety status in cosmetics vs industrial chemicals?
Butyl Glycolate is classified GHS Danger (H318, H227, H319, H361) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Butyl Glycolate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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