NOAEL Studies
Cosmetic Ingredient
Butyl Glycolate NOAEL Studies
INCI: BUTYL GLYCOLATE
CAS: 7397-62-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =4240 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_9866; row=10904; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl hydroxyacetate; preferred_name=Butyl hydroxyacetate; dtxsid=DTXSID6044725; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4595 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_9868; row=10905; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl hydroxyacetate; preferred_name=Butyl hydroxyacetate; dtxsid=DTXSID6044725; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4825 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_9870; row=10903; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl hydroxyacetate; preferred_name=Butyl hydroxyacetate; dtxsid=DTXSID6044725; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725; source_file=acute_oral.xlsx |
NTP_ICE_skin_irritation 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Viability (240 minutes) | 74.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4433; Record_ID=skin_irritation_invitro_1940; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=74.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 82.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4432; Record_ID=skin_irritation_invitro_1938; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=82.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 94.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4434; Record_ID=skin_irritation_invitro_1887; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=94.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 88.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4435; Record_ID=skin_irritation_invitro_1940; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=88.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 96.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4429; Record_ID=skin_irritation_invitro_1887; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=96.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 110.9 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4440; Record_ID=skin_irritation_invitro_1938; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=110.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 92.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4430; Record_ID=skin_irritation_invitro_1940; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=92.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 105.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4431; Record_ID=skin_irritation_invitro_1887; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=105.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 108.2 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4436; Record_ID=skin_irritation_invitro_1938; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6044725; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=108.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044725 |
ToxValDB_ECHA_IUCLID 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =1640 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab48e4b0a7c65d1b9ae8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23612/7/9/2?documentUUID=86ededf0-9aa9-4bf3-8b80-ccc69f324613; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15860648:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8c685da00f590296efc9307811891b60 |
| ToxValDB_ECHA_IUCLID | LEL | =1798 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab48e4b0a7c65d1b9ada; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23612/7/9/2?documentUUID=86ededf0-9aa9-4bf3-8b80-ccc69f324613; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15861693:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_833042a63985aba9e4c913eef42a6b0f |
| ToxValDB_ECHA_IUCLID | LEL | >6200 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23612/7/3/3?documentUUID=86ededf0-9aa9-4bf3-8b80-ccc69f324613; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15796532:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b9977ce7e720a643021113855a1beac9 |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb67c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23612/7/6/2?documentUUID=86ededf0-9aa9-4bf3-8b80-ccc69f324613; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15849128:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4da879d531efb69cb2e462aa3314eff |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bed45; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23612/7/9/3?documentUUID=86ededf0-9aa9-4bf3-8b80-ccc69f324613; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15823387:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7fa486a2be429e802752156e7ed2b99d |
| ToxValDB_ECHA_IUCLID | NOAEL | >2000 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bed45; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23612/7/9/3?documentUUID=86ededf0-9aa9-4bf3-8b80-ccc69f324613; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15823590:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_db140c53a9ded86a848b22e96a849fa5 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =7.05 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632656:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f9160d0fc07d9545aeae0ffda26d78c |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 3H5QAS0HZX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3H5QAS0HZX"} |
| openFDA substances | FDA UNII substance identifier | 3H5QAS0HZX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3H5QAS0HZX"} |
| openFDA substances | FDA UNII substance identifier | 3H5QAS0HZX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3H5QAS0HZX"} |
| openFDA substances | FDA UNII substance identifier | 3H5QAS0HZX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3H5QAS0HZX"} |