What is the NOAEL for Butyl hydroxyacetate?
Butyl hydroxyacetate has 23 NOAEL studies in the database. The lowest reported value is 7.05 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butyl hydroxyacetate
Also known as: Acetic acid, hydroxy-, butyl ester, EINECS 230-991-7, Polysolvan 0
CAS 7397-62-8
Butyl hydroxyacetate (CAS 7397-62-8) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Butyl hydroxyacetate is classified GHS Danger (H318, H227, H319, H361) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
23
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Butyl hydroxyacetate
CAS Number
7397-62-8
DTXSID
DTXSID6044725
Molecular Formula
C6H12O3
InChI Key
VFGRALUHHHDIQI-UHFFFAOYSA-N
Monoisotopic Mass
132.078644
Synonyms
Acetic acid, hydroxy-, butyl esterEINECS 230-991-7Polysolvan 0
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Softener and conditionerSolvent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =7.05 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3H5QAS0HZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3H5QAS0HZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3H5QAS0HZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3H5QAS0HZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =4240 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4595 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4825 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1640 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1798 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >6200 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >2000 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| 74.5 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 82.6 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 94.1 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 88.7 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 96.1 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 110.9 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 92.6 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 105.7 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 108.2 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 23 of 23 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butyl glycollate | 230-991-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184386
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is Butyl hydroxyacetate used in cosmetics?
Yes, Butyl hydroxyacetate is also indexed as a cosmetic ingredient under the name Butyl Glycolate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butyl hydroxyacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Butyl hydroxyacetate have different safety status in cosmetics vs industrial chemicals?
Butyl hydroxyacetate is classified GHS Danger (H318, H227, H319, H361) in the chemicals database but is restricted in EU cosmetics.
Is Butyl hydroxyacetate used outside industrial chemicals?
Butyl hydroxyacetate also appears in cosmetics, pharmaceutical databases.