Is Bispyrithione safe in cosmetics?
Bispyrithione has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Bispyrithione
Also known as: 5-21-02-00055, Bis(N-oxido-2-pyridyl) disulfide, Bis(2-pyridine-N-oxide) disulfide, Bis(2-pyridyl) disulfide di-N-oxide, Bis(2-pyridyl-N-oxide) disulfide (+14 more)
INCI: BISPYRITHIONE
Bispyrithione (CAS 3696-28-4) is a cosmetic cosmetic ingredient functioning as Antimicrobial, anti-dandruff agent, preservative (disulfide dimer of pyrithione). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3696-28-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Bispyrithione is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335, H400).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial, anti-dandruff agent, preservative (disulfide dimer of pyrithione)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-oxido-2-[(1-oxidopyridin-1-ium-2-yl)disulfanyl]pyridin-1-ium
InChIKey
ZHDBTKPXEJDTTQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
FDA: Zinc pyrithione is an approved OTC anti-dandruff active (21 CFR 358.710). Bispyrithione itself does not have separate FDA monograph status. CIR has not issued a standalone review.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bispyrithione.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for Bispyrithione.
Regulatory Flags
preservative
Known Synonyms
5-21-02-00055
Bis(N-oxido-2-pyridyl) disulfide
Bis(2-pyridine-N-oxide) disulfide
Bis(2-pyridyl) disulfide di-N-oxide
Bis(2-pyridyl-N-oxide) disulfide
Bis(2-pyridyl-1-oxide) disulfide
BRN 0217725
2,2'-Dithiobis(pyridine 1,1'-dioxide)
2,2'-Dithiobis(pyridine 1-oxide)
2,2'-Dithiodipyridine-1,1'-dioxide
EINECS 223-024-5
NSC 241716
NSC 84740
Omadine disulfide
Omadine DS
Dipiritiona
Dipyrithionum
UNII-9L87N86R9A
Pyridine, 2,2'-dithiobis-, 1,1'-dioxide
Chemical Function
Biocide
Regulatory Lists
pharmaceutical
active_ingredient; Europe; Pesticides
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIPYRITHIONE
ChEMBL ID
CHEMBL549473
Max Phase
2
Frequently Asked Questions
Is Bispyrithione allowed in the EU?
Bispyrithione EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Bispyrithione do in cosmetics?
Bispyrithione functions as: Antimicrobial, anti-dandruff agent, preservative (disulfide dimer of pyrithione). It is classified as a cosmetic ingredient in our database. CAS number: 3696-28-4.
Is Bispyrithione used outside cosmetics?
Bispyrithione also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Bispyrithione have different safety status in cosmetics vs industrial chemicals?
Bispyrithione is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335, H400).
Compliance Tools
Check Bispyrithione compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Film Forming
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