What is the NOAEL for Dipyrithione?
Dipyrithione has 4 NOAEL studies in the database. The lowest reported value is 9L87N86R9A UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Dipyrithione
Also known as: 5-21-02-00055, Bis(N-oxido-2-pyridyl) disulfide, Bis(2-pyridine-N-oxide) disulfide, Bis(2-pyridyl) disulfide di-N-oxide, Bis(2-pyridyl-N-oxide) disulfide (+14 more)
CAS 3696-28-4
Dipyrithione (CAS 3696-28-4) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Dipyrithione is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335, H400).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Dipyrithione
CAS Number
3696-28-4
DTXSID
DTXSID1041897
Molecular Formula
C10H8N2O2S2
InChI Key
ZHDBTKPXEJDTTQ-UHFFFAOYSA-N
Monoisotopic Mass
252.00272
Synonyms
5-21-02-00055Bis(N-oxido-2-pyridyl) disulfideBis(2-pyridine-N-oxide) disulfideBis(2-pyridyl) disulfide di-N-oxideBis(2-pyridyl-N-oxide) disulfideBis(2-pyridyl-1-oxide) disulfideBRN 02177252,2'-Dithiobis(pyridine 1,1'-dioxide)2,2'-Dithiobis(pyridine 1-oxide)2,2'-Dithiodipyridine-1,1'-dioxideEINECS 223-024-5NSC 241716
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Biocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9L87N86R9A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L87N86R9A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L87N86R9A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L87N86R9A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIPYRITHIONE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Dipyrithione?
Dipyrithione appears on 4 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, Canada; pharmaceutical, and 1 more. Source: EPA CPDat.
Is Dipyrithione used in cosmetics?
Yes, Dipyrithione is also indexed as a cosmetic ingredient under the name Bispyrithione. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dipyrithione come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dipyrithione have different safety status in cosmetics vs industrial chemicals?
Dipyrithione is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335, H400).
Is Dipyrithione used outside industrial chemicals?
Dipyrithione also appears in cosmetics, pharmaceutical databases.