Is Bisabolene safe in cosmetics?
Bisabolene has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Bisabolene
Also known as: EINECS 207-805-8, FEMA No. 3331, 2-Heptene, 2-methyl-6-(4-methyl-3-cyclohexen-1-ylidene)-, 1-Methyl-4-(1,5-dimethyl-4-hexenylidene)-1-cyclohexene, UNII-E6941S3U3Q (+5 more)
INCI: BISABOLENE
Bisabolene (CAS 495-62-5) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 495-62-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Bisabolene is classified GHS Danger (H304, H315, H317) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-methyl-4-(6-methylhept-5-en-2-ylidene)cyclohexene
InChIKey
XBGUIVFBMBVUEG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
RIFM safety assessment completed — safe as used at reported levels; evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, skin sensitization, phototoxicity, and environmental safety
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bisabolene.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1336
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BISABOLENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Bisabolene.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
EINECS 207-805-8
FEMA No. 3331
2-Heptene, 2-methyl-6-(4-methyl-3-cyclohexen-1-ylidene)-
1-Methyl-4-(1,5-dimethyl-4-hexenylidene)-1-cyclohexene
UNII-E6941S3U3Q
2-methyl-6-(4-methyl-3-cyclohexen-1-ylidene)-2-heptene
4-(1,5-dimethyl-4-hexenylidene)-1-methylcyclohexene
gamma-Bisabolen
limene
gamma-bisabolene
Chemical Function
Fragrance
Flavouring and nutrient
Biocide
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Bisabolene allowed in the EU?
Bisabolene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bisabolene do in cosmetics?
Bisabolene functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 495-62-5.
Is Bisabolene used outside cosmetics?
Bisabolene also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Bisabolene have different safety status in cosmetics vs industrial chemicals?
Bisabolene is classified GHS Danger (H304, H315, H317) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Bisabolene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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