Is Hippuric Acid safe in cosmetics?
Hippuric Acid has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hippuric Acid
Also known as: 4-09-00-00778, BRN 1073987, EINECS 207-806-3, N-Benzoyl-glycin, Acido ippurico (+14 more)
INCI: HIPPURIC ACID
Hippuric Acid (CAS 495-69-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning (N-Benzoylglycine; endogenous metabolite of benzoic acid). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 495-69-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hippuric Acid is classified GHS Danger (H302, H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning (N-Benzoylglycine; endogenous metabolite of benzoic acid)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-benzamidoacetic acid
InChIKey
QIAFMBKCNZACKA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hippuric Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Hippuric Acid.
Known Synonyms
4-09-00-00778
BRN 1073987
EINECS 207-806-3
N-Benzoyl-glycin
Acido ippurico
UNII-TE0865N2ET
(benzoylamino)-Acetate
(benzoylamino)-Acetic acid
2-(benzoylamino)acetic acid
2-(phenylcarbonylamino)ethanoic acid
2-(phenylformamido)acetic acid
2-Benzamidoacetate
2-[(oxo-phenylmethyl)amino]acetic acid
Benzamidoacetate
Benzamidoessigsaeure
Benzoylaminoessigsaeure
Hippurate
Phenylcarbonylaminoacetate
Phenylcarbonylaminoacetic acid
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HIPPURIC ACID
ChEMBL ID
CHEMBL461
Frequently Asked Questions
Is Hippuric Acid allowed in the EU?
Hippuric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hippuric Acid do in cosmetics?
Hippuric Acid functions as: Skin conditioning (N-Benzoylglycine; endogenous metabolite of benzoic acid). It is classified as a cosmetic ingredient in our database. CAS number: 495-69-2.
Is Hippuric Acid used outside cosmetics?
Hippuric Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hippuric Acid have different safety status in cosmetics vs industrial chemicals?
Hippuric Acid is classified GHS Danger (H302, H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Hippuric Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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