Is BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE safe in cosmetics?
BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE has a safety rating of "GOOD" in our database. EU status: permitted. 2 toxicological study endpoint(s) are available in our database.
BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE
Also known as: BBOT, 2,5-Bis(5-tert-butylbenzoxazol-2-yl)thiophene, Benzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-(1,1-dimethylethyl)-, Benzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-tert-butyl-, 2,2'-(2,5-Thiophenediyl)bis[5-tert-butylbenzoxazole] (+15 more)
BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE (CAS 7128-64-5) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. Reported NOAEL =2500 mg/kg bw/day in Dog (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 7128-64-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
5-tert-butyl-2-[5-(5-tert-butyl-1,3-benzoxazol-2-yl)thiophen-2-yl]-1,3-benzoxazole
InChIKey
AIXZBGVLNVRQSS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
2 study endpoints found for BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2500 mg/kg bw/day | oral | Dog | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =7800 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Brightener
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE by CAS number or substance name.
Studies
2
Lowest NOAEL
2500 mg/kg bw/day
Highest NOAEL
7800 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
BBOT
2,5-Bis(5-tert-butylbenzoxazol-2-yl)thiophene
Benzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-(1,1-dimethylethyl)-
Benzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-tert-butyl-
2,2'-(2,5-Thiophenediyl)bis[5-tert-butylbenzoxazole]
2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene
2,5-Bis(5-tert-butylbenzooxazol-2-yl)thiophene
2,5-Bis(5'-tert-butyl-2-benzoxazolyl)thiophene
2,5-Di(5-tert-butylbenzoxazol-2-yl)thiophene
BBOT 150
Benetex OB
Brightener OB
C.I. 515245
C.I. FBA 184
C.I. Fluorescent Brightener 184
C.I. Fluorescent Brightening Agent 184
Fluorescent Brightener 184
Helios SC
Hitex OB
Keyfluor White PL
Chemical Function
Softener and conditioner
Brightener
Regulatory Lists
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Frequently Asked Questions
Is BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE allowed in the EU?
BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE do in cosmetics?
BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 7128-64-5.
What is the NOAEL for BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE?
The NOAEL (No Observed Adverse Effect Level) for BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE is =2500 mg/kg bw/day based on a subchronic study via oral route in Dog. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE used outside cosmetics?
BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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MoS Calculator
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