NOAEL Data REACH Registered Cosmetic Ingredient

2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole]

Also known as: BBOT, 2,5-Bis(5-tert-butylbenzoxazol-2-yl)thiophene, Benzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-(1,1-dimethylethyl)-, Benzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-tert-butyl-, 2,2'-(2,5-Thiophenediyl)bis[5-tert-butylbenzoxazole] (+15 more)

CAS 7128-64-5

2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] (CAS 7128-64-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole]

CAS Number

7128-64-5

DTXSID

DTXSID1048205

Molecular Formula

C26H26N2O2S

InChI Key

AIXZBGVLNVRQSS-UHFFFAOYSA-N

Monoisotopic Mass

430.171499

Synonyms

BBOT2,5-Bis(5-tert-butylbenzoxazol-2-yl)thiopheneBenzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-(1,1-dimethylethyl)-Benzoxazole, 2,2'-(2,5-thiophenediyl)bis[5-tert-butyl-2,2'-(2,5-Thiophenediyl)bis[5-tert-butylbenzoxazole]2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene2,5-Bis(5-tert-butylbenzooxazol-2-yl)thiophene2,5-Bis(5'-tert-butyl-2-benzoxazolyl)thiophene2,5-Di(5-tert-butylbenzoxazol-2-yl)thiopheneBBOT 150Benetex OBBrightener OB

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 27 records

Softener and conditionerBrightener

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 16 of 16 studies

Value	Unit	Endpoint	Route	Species	Source
=3	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
W7UR9129GP	UNII	FDA UNII substance identifier	-	-	openFDA substances
W7UR9129GP	UNII	FDA UNII substance identifier	-	-	openFDA substances
W7UR9129GP	UNII	FDA UNII substance identifier	-	-	openFDA substances
W7UR9129GP	UNII	FDA UNII substance identifier	-	-	openFDA substances
>10000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
3000	ppm	LOAEL	oral	rat	COSMOS_DB
1000	ppm	NOAEL	oral	rat	COSMOS_DB
=2500	mg/kg bw/day	NOAEL	oral	Dog	ToxValDB_ECHA_IUCLID
5000	ppm	NOAEL	oral	dog	COSMOS_DB
=7800	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=78	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=185	mg/kg bw/day	NOEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=1000	ppm	NOEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=1571	mg/kg bw/day	NOEL	oral	Dog	ToxValDB_ECHA_IUCLID
=1682	mg/kg bw/day	NOEL	oral	Dog	ToxValDB_ECHA_IUCLID

Showing 16 of 16 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2,5-thiophenediylbis(5-tert-butyl-1,3-benzoxazole)	230-426-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the NOAEL for 2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole]?

2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] has 16 NOAEL studies in the database. The lowest reported value is 3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole]?

2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] appears on 3 regulatory/inventory lists including Indirect additives food contact (10/2018), inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.

Is 2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] used in cosmetics?

Yes, 2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] is also indexed as a cosmetic ingredient under the name BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] used outside industrial chemicals?

2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole] also appears in cosmetics databases.