NOAEL Studies Cosmetic Ingredient

BIS(T-BUTYL BENZOXAZOLYL) THIOPHENE NOAEL Studies

CAS: 7128-64-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 3000 ppm rat oral 90 day Subchronic FAP; Toxicity in Dietary Administration to Rats for 13 Weeks
COSMOS_DB NOAEL 1000 ppm rat oral 90 day Subchronic FAP; Toxicity in Dietary Administration to Rats for 13 Weeks
COSMOS_DB NOAEL 5000 ppm dog oral 90 day Subchronic FAP; 3-Month Subchronic Dietary Toxicity Study in Beagle Dogs
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9626; row=3249; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Bis(5-tert-butylbenzoxazol-2-yl)thiophene; preferred_name=2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole]; dtxsid=DTXSID1048205; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1048205; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =2500 mg/kg bw/day Dog oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10402/7/6/2?documentUUID=433ea4c7-4686-42b2-8e87-e74457f2faf7; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15849774:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_df714a3fcd46cf56ef6c129a00e03509
ToxValDB_ECHA_IUCLID NOAEL =7800 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2ec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10402/7/6/2?documentUUID=433ea4c7-4686-42b2-8e87-e74457f2faf7; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15851013:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_de151611f100d2b10a7958749fe46795
ToxValDB_ECHA_IUCLID NOEL =78 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4467; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10402/7/8?documentUUID=433ea4c7-4686-42b2-8e87-e74457f2faf7; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816526_15820187:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d9b1ef4a217c283bd21a90ba297ba2b4
ToxValDB_ECHA_IUCLID NOEL =185 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4469; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10402/7/8?documentUUID=433ea4c7-4686-42b2-8e87-e74457f2faf7; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816815_15820188:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_959c53bca74c3439e3d5a878bbc25b03
ToxValDB_ECHA_IUCLID NOEL =1000 ppm Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c93de4b0a7c65d21c127; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10402/7/9/2?documentUUID=433ea4c7-4686-42b2-8e87-e74457f2faf7; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15857440:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fffca8215d2f0beb6b4a2b50da142e05
ToxValDB_ECHA_IUCLID NOEL =1571 mg/kg bw/day Dog oral chronic; 93 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2f2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10402/7/6/2?documentUUID=433ea4c7-4686-42b2-8e87-e74457f2faf7; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15848664:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3f61a7a89e100f9446654a494d318a53
ToxValDB_ECHA_IUCLID NOEL =1682 mg/kg bw/day Dog oral chronic; 93 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2f2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10402/7/6/2?documentUUID=433ea4c7-4686-42b2-8e87-e74457f2faf7; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15847896:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2fad9ac6c2eee0ad0ce9a1417be7bf38
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635240_15635241:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dcf357cc6038fa640d184dd984f76d8e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier W7UR9129GP UNII - - - chemical {"approval_status":null,"molecular_formula":"C26H26N2O2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W7UR9129GP"}
openFDA substances FDA UNII substance identifier W7UR9129GP UNII - - - chemical {"approval_status":null,"molecular_formula":"C26H26N2O2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W7UR9129GP"}
openFDA substances FDA UNII substance identifier W7UR9129GP UNII - - - chemical {"approval_status":null,"molecular_formula":"C26H26N2O2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W7UR9129GP"}
openFDA substances FDA UNII substance identifier W7UR9129GP UNII - - - chemical {"approval_status":null,"molecular_formula":"C26H26N2O2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"W7UR9129GP"}