Is Bergapten safe in cosmetics?
Bergapten has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted.
Poor
Cosmetic Ingredient
Bergapten
Also known as: 5-19-06-00004, BRN 0019560, EINECS 207-604-5, 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone, 5-Methoxy psoralen (+4 more)
INCI: BERGAPTEN
Bergapten (CAS 484-20-8) is a cosmetic cosmetic ingredient functioning as UV filter, fragrance, masking. EU Regulation 1223/2009 status: restricted, max Below 1 mg/kg in sun protection and bronzing products; permitted as natural trace in essences. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 484-20-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Bergapten is classified GHS Danger (H341, H350, H361, H370, H373, H334, H340, H317) in the chemicals database but is restricted in EU cosmetics at max Below 1 mg/kg in sun protection and bronzing products; permitted as natural trace in essences.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
UV filter, fragrance, masking
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-methoxyfuro[3,2-g]chromen-7-one
InChIKey
BGEBZHIAGXMEMV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
Below 1 mg/kg in sun protection and bronzing products; permitted as natural trace in essences
US US Status
restricted
US Notes
FDA restricts furocoumarin-containing ingredients in leave-on products; not an approved OTC UV filter; phototoxicity concern
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bergapten.
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2A
Volume
40, Sup 7
Evaluation Year
1987
NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
5-Methoxypsoralen | Group 2A: Probably carcinogenic to humans | Volume 40: (1986) Some Naturally Occurring and Synthetic Food Components, Furocoumarins and Ultraviolet Radiation | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | NB Overall evaluation upgraded to Group 2A with supporting eviden
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Inadequate evidence of carcinogenicity in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2A: The agent is probably carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Bergapten.
Regulatory Flags
photosensitizer
phototoxic
photoallergen
restricted-EU
furocoumarin
prop65
Known Synonyms
5-19-06-00004
BRN 0019560
EINECS 207-604-5
6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone
5-Methoxy psoralen
UNII-4FVK84C92X
4-methoxy-7-furo[3,2-g][1]benzopyranone
4-methoxyfuro[3,2-g]chromen-7-one
5-methoxypsoralene
Regulatory Lists
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BERGAPTEN
ChEMBL ID
CHEMBL24171
Max Phase
3
Frequently Asked Questions
Is Bergapten allowed in the EU?
Bergapten EU regulatory status: restricted. Maximum allowed concentration: Below 1 mg/kg in sun protection and bronzing products; permitted as natural trace in essences. This is based on EU Regulation 1223/2009 and its amendments.
What does Bergapten do in cosmetics?
Bergapten functions as: UV filter, fragrance, masking. It is classified as a cosmetic ingredient in our database. CAS number: 484-20-8.
Is Bergapten used outside cosmetics?
Bergapten also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Bergapten have different safety status in cosmetics vs industrial chemicals?
Bergapten is classified GHS Danger (H341, H350, H361, H370, H373, H334, H340, H317) in the chemicals database but is restricted in EU cosmetics at max Below 1 mg/kg in sun protection and bronzing products; permitted as natural trace in essences.
Compliance Tools
Check Bergapten compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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