Is Benzyl Acetone safe in cosmetics?
Benzyl Acetone has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Benzyl Acetone
Also known as: 4-07-00-00713, BRN 1907123, EINECS 219-847-4, Methyl phenylethyl ketone, beta-Phenylethyl methyl ketone
INCI: BENZYL ACETONE
Benzyl Acetone (CAS 2550-26-7) is a cosmetic cosmetic ingredient functioning as Perfuming / Fragrance ingredient. Reported NOAEL =165 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2550-26-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Benzyl Acetone is prohibited in EU cosmetics but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word
Function
Perfuming / Fragrance ingredient
Safety Rating
GOOD
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted for cosmetic use; no specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzyl Acetone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Benzyl Acetone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =165 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =500 mg/kg bw/day | oral | Rat | subchronic | ECHA |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
837 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [472] Epstein WL (1980): Report to RIFM, 14 April, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
| HRIPT | - | 0 | 837 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "2550-26-7", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.095", "ifra_max_use_level_category_4_pct": "1.5", "ifra_max_use_level_category_7_pct": "0.22", "ifra_max_use_level_category_11_pct": "0.042", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Benzyl Acetone.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Benzyl Acetone by CAS number or substance name.
Studies
2
Lowest NOAEL
165 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ECHA
Known Synonyms
4-07-00-00713
BRN 1907123
EINECS 219-847-4
Methyl phenylethyl ketone
beta-Phenylethyl methyl ketone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BENZYLACETONE
ChEMBL ID
CHEMBL1490851
Frequently Asked Questions
Is Benzyl Acetone allowed in the EU?
Benzyl Acetone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzyl Acetone do in cosmetics?
Benzyl Acetone functions as: Perfuming / Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2550-26-7.
What is the NOAEL for Benzyl Acetone?
The NOAEL (No Observed Adverse Effect Level) for Benzyl Acetone is =165 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
Is Benzyl Acetone used outside cosmetics?
Benzyl Acetone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Benzyl Acetone have different safety status in cosmetics vs industrial chemicals?
Benzyl Acetone is prohibited in EU cosmetics but has active industrial GHS classifications.
Compliance Tools
Check Benzyl Acetone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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