NOAEL Studies Cosmetic Ingredient

Benzyl Acetone NOAEL Studies

INCI: BENZYL ACETONE

CAS: 2550-26-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE skin irritation 31 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation Viability (240 minutes) 137.1 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4271; Record_ID=skin_irritation_invitro_1879; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=137.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (240 minutes) 143.4 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4269; Record_ID=skin_irritation_invitro_1881; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=143.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (240 minutes) 149.9 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4270; Record_ID=skin_irritation_invitro_1880; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=149.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 66.1 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4300; Record_ID=skin_irritation_invitro_1859; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=66.10; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 87 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4298; Record_ID=skin_irritation_invitro_1863; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=87; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 89.9 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4291; Record_ID=skin_irritation_invitro_1876; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=89.9; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 92.3 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4290; Record_ID=skin_irritation_invitro_1878; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=92.3; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 96.5 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4299; Record_ID=skin_irritation_invitro_1861; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=96.5; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 99.2 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4293; Record_ID=skin_irritation_invitro_1873; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=99.2; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 101.9 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4292; Record_ID=skin_irritation_invitro_1875; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=101.9; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 102.3 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4297; Record_ID=skin_irritation_invitro_1865; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=102.3; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 103.2 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4295; Record_ID=skin_irritation_invitro_1869; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=103.2; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 103.3 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4294; Record_ID=skin_irritation_invitro_1871; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=103.3; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 118.7 % - Dermal - In Vitro; LabCyte Corrosion sheet=Data_invitro; excel_row=4296; Record_ID=skin_irritation_invitro_1867; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=LabCyte Corrosion; Endpoint=Viability (3 minutes); Response=118.7; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 133.2 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4289; Record_ID=skin_irritation_invitro_1879; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=133.20; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 134.7 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4288; Record_ID=skin_irritation_invitro_1880; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=134.70; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (3 minutes) 150.3 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4287; Record_ID=skin_irritation_invitro_1881; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=150.30; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 72.4 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4285; Record_ID=skin_irritation_invitro_1861; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=72.40; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 74.1 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4268; Record_ID=skin_irritation_invitro_1863; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=74.10; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 77.6 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4283; Record_ID=skin_irritation_invitro_1865; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=77.60; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 78.4 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=4286; Record_ID=skin_irritation_invitro_1859; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=78.40; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 81 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4279; Record_ID=skin_irritation_invitro_1869; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=81; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 86.6 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4276; Record_ID=skin_irritation_invitro_1876; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=86.6; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 88.1 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4278; Record_ID=skin_irritation_invitro_1873; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=88.1; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 91.9 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4267; Record_ID=skin_irritation_invitro_1871; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=91.9; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 93.5 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4277; Record_ID=skin_irritation_invitro_1875; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=93.5; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 100.4 % - Dermal - In Vitro; LabCyte Corrosion sheet=Data_invitro; excel_row=4280; Record_ID=skin_irritation_invitro_1867; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=LabCyte Corrosion; Endpoint=Viability (60 minutes); Response=100.4; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 104.6 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=4275; Record_ID=skin_irritation_invitro_1878; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=104.6; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 141.2 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4274; Record_ID=skin_irritation_invitro_1879; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=141.20; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 142.2 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4272; Record_ID=skin_irritation_invitro_1881; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=142.20; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin irritation Viability (60 minutes) 151.3 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=4273; Record_ID=skin_irritation_invitro_1880; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=151.30; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin sensitization 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6362; Record_ID=skin_sensitization_invivo_1460; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1983; Not available; 10.1016/0278-6915(83)90155-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin sensitization Induction dose per skin area 837 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6376; Record_ID=skin_sensitization_invivo_1464; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=837; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31247259; 10.1016/j.fct.2019.110605; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin sensitization Induction dose per skin area 1240 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6368; Record_ID=skin_sensitization_invivo_1462; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31247259; 10.1016/j.fct.2019.110605; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin sensitization Induction dose per skin area 1350 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6360; Record_ID=skin_sensitization_invivo_1460; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1983; Not available; 10.1016/0278-6915(83)90155-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6366; Record_ID=skin_sensitization_invivo_1460; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1983; Not available; 10.1016/0278-6915(83)90155-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
NTP ICE skin sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6374; Record_ID=skin_sensitization_invivo_1462; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6033241; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31247259; 10.1016/j.fct.2019.110605; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6033241
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =165 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a99; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20508/7/6/2?documentUUID=56bb632d-0ae1-4c3a-9e02-ac36ec28d159; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837052_15837053:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2bb58eeecc0e2449487e6669d55b00b1
ECHA NOAEL =500 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a99; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20508/7/6/2?documentUUID=56bb632d-0ae1-4c3a-9e02-ac36ec28d159; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837052_15837053:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c559d01f183e5f15edbd32c94b563dd
ECHA NOEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20508/7/9/3?documentUUID=56bb632d-0ae1-4c3a-9e02-ac36ec28d159; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECHA IUCLID:15821669:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d58117e29da603bff180ef811bd9c50f
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =17.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630053:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca307b4803046d875a78a8a584f5b112
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier UZM5QH16YW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UZM5QH16YW"}
openFDA substances FDA UNII substance identifier UZM5QH16YW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UZM5QH16YW"}
openFDA substances FDA UNII substance identifier UZM5QH16YW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UZM5QH16YW"}
openFDA substances FDA UNII substance identifier UZM5QH16YW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UZM5QH16YW"}