Is Ascorbyl Tetraisopalmitate safe in cosmetics?
Ascorbyl Tetraisopalmitate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
Ascorbyl Tetraisopalmitate
Also known as: 2,3,5,6-O-Tetra-2'-hexyldecanoyl-L-ascorbic acid, Ascorbyl tetra-2-hexyldecanoate, Vitamin C tetra-isopalmitate
INCI: ASCORBYL TETRAISOPALMITATE
Ascorbyl Tetraisopalmitate (CAS 183476-82-6) is a cosmetic active ingredient functioning as Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 183476-82-6 →
Auto-generated CPSR Part A draft with source citations
Function
Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires esterase-mediated hydrolysis to release ascorbic acid in skin; brightening active in anhydrous and oil-dominant formulations
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction. Allergic contact dermatitis cases published; use with caution. Not recommended as primary brightening active where alternatives with better safety records exist.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ascorbyl Tetraisopalmitate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "183476-82-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "2", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restricti…
anti_aging
{"anti_aging_claim": "anti-wrinkle, brightening, antioxidant-protection", "mechanism_of_action": "Oil-soluble vitamin C, penetrates lipid barrier, converted intracellularly", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Moderate-High", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "20", "double_blind":…
antioxidant
{"cas_number": "183476-82-6", "antioxidant_class": "vitamin", "chemical_subclass": "tetrasubstituted lipophilic ascorbic acid", "molecular_weight_daltons": "1129.8", "orac_value_umol_te_per_g": "1500", "dpph_radical_scavenging_ic50_ug_per_ml": "20-35", "abts_trolox_equivalent": "0.7", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "hi…
baby_pediatric
{"cas_number": "CAS-FUNC-31", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Functional ingredient - generally safe", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern…
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.5", "product_type": "Moisturizer", "function_at_concentration": "Oil-soluble vitamin C", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "180", "estimated_cost_per_kg_usd_high": "320", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Japan", "bulk_discount_threshold_kg": "10", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Ethyl Ascorbic A…
ph_stability
{"stable_ph_min": "3.0", "stable_ph_max": "9.0", "ph_dependent_function": "Oil-soluble, highly stable", "formulation_note": "Most stable vitamin C derivative, lipophilic", "source": "Vivify 2026"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Oil-soluble vitamin C; safe", "source": "dermatology literature"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Ascorbyl Tetraisopalmitate.
Regulatory Flags
cir-safe-as-used-2022
eu-unrestricted
oil-soluble
superior-stability
lipophilic
korea-functional-cosmetic-whitening
Known Synonyms
2,3,5,6-O-Tetra-2'-hexyldecanoyl-L-ascorbic acid
Ascorbyl tetra-2-hexyldecanoate
Vitamin C tetra-isopalmitate
Chemical Function
Antioxidant
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Ascorbyl Tetraisopalmitate allowed in the EU?
Ascorbyl Tetraisopalmitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ascorbyl Tetraisopalmitate do in cosmetics?
Ascorbyl Tetraisopalmitate functions as: Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires esterase-mediated hydrolysis to release ascorbic acid in skin; brightening active in anhydrous and oil-dominant formulations. It is classified as a Active Ingredient in our database. CAS number: 183476-82-6.
Is Ascorbyl Tetraisopalmitate used outside cosmetics?
Ascorbyl Tetraisopalmitate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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