Is Tetrahexyldecyl Ascorbate safe in cosmetics?
Tetrahexyldecyl Ascorbate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Tetrahexyldecyl Ascorbate
Also known as: 2,3,5,6-O-Tetra-2'-hexyldecanoyl-L-ascorbic acid, Ascorbyl tetra-2-hexyldecanoate, Vitamin C tetra-isopalmitate
INCI: TETRAHEXYLDECYL ASCORBATE
Tetrahexyldecyl Ascorbate (CAS 183476-82-6) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning (oil-soluble Vitamin C derivative). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 183476-82-6 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning (oil-soluble Vitamin C derivative)
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR reviewed and found safe as used in the ethers/esters of ascorbic acid group
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahexyldecyl Ascorbate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
9 property records from structured ingredient metadata.
acne
{"cas_number": "183476-82-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "2", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restricti…
anti_pollution
{"cas_number": "183476-82-6", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_mo…
comedogenicity_detail
{"comedogenicity_rating": "1", "irritancy_rating": "1", "skin_type_suitability": "all,oily,combination,normal,mature", "acne_safe": "yes", "source": "Oil-soluble vitamin C"}
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "10.0", "typical_concentration_pct": "5.0", "product_type": "Facial Oil", "function_at_concentration": "Stable vitamin C", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "220", "estimated_cost_per_kg_usd_high": "400", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Japan/Europe", "bulk_discount_threshold_kg": "10", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Ascorbyl …
skin_suitability
{"oily_skin": "recommended", "dry_skin": "recommended", "sensitive_skin": "acceptable", "combination_skin": "recommended", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "recommended", "aging_mature": "recommended", "dehydrated": "acceptable", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "brightenin…
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "soluble_in": "oils, ethanol", "insoluble_in": "water, glycerin, propylene glycol", "log_p": "18.5", "appearance": "pale yellow liquid", "source": "Nikko"}
synergy
{"inci_name_2": "Resveratrol", "synergy_type": "antioxidant-synergy", "synergy_description": "Oil-soluble vitamin C with polyphenol for lipid antioxidant power", "combined_benefit": "Superior lipid membrane protection, enhanced stability, longevity activation", "efficacy_multiplier": "2.1x", "mechanism_of_action": "THDA provides stable lipid-phase vitamin C; resveratrol adds sirtuin activation and…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Tetrahexyldecyl Ascorbate.
Known Synonyms
2,3,5,6-O-Tetra-2'-hexyldecanoyl-L-ascorbic acid
Ascorbyl tetra-2-hexyldecanoate
Vitamin C tetra-isopalmitate
Chemical Function
Antioxidant
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Tetrahexyldecyl Ascorbate allowed in the EU?
Tetrahexyldecyl Ascorbate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahexyldecyl Ascorbate do in cosmetics?
Tetrahexyldecyl Ascorbate functions as: Antioxidant, skin conditioning (oil-soluble Vitamin C derivative). It is classified as a cosmetic ingredient in our database. CAS number: 183476-82-6.
Is Tetrahexyldecyl Ascorbate used outside cosmetics?
Tetrahexyldecyl Ascorbate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tetrahexyldecyl Ascorbate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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