Is Amyl Cinnamal safe in cosmetics?
Amyl Cinnamal has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Amyl Cinnamal
Also known as: alpha- Amyl cinnamal, 2-(Phenylmethylene)heptanal, 2-Benzylideneheptanal, Pentylcinnamaldehyde, 2-(Phenylmethylene)-heptanal (+15 more)
INCI: AMYL CINNAMAL
Amyl Cinnamal (CAS 122-40-7) is a cosmetic fragrance functioning as Fragrance. NOAEL 23 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 122-40-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
EU Max Conc.
Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%
US US Status
permitted
US Notes
IFRA standard restricts use level by product category; fragrance industry QRA2 framework applies
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Amyl Cinnamal.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Amyl Cinnamal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 6 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =0.04 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| NOAEL | =23 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =36 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Amyl Cinnamal across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for Amyl Cinnamal based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.3%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted
— max 0.1% in finished products
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Amyl Cinnamal, relevant to systemic exposure and MoS calculations.
Absorption %
15-25%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
188.3 Da
Log P
4.2
Systemic Absorption
yes
Topical Bioavailability
10-20%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation
Source: SCCS/1459/11, IFRA
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg-day | Rat | oral | chronic | EFSA |
| LD50 | >2000 mg/kg | Rabbit | dermal | - | ECHA IUCLID |
| LD50 | =3100 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =3700 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =2220 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =3730 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | =23 mg/kg-day | Rat | oral | chronic | ECHA IUCLID |
| NOAEL | =36 mg/kg-day | Rat | oral | chronic | ECHA IUCLID |
| LOEL | =30 % | Mouse | dermal | short-term | ECOTOX |
| LD50 | =3730 mg/kg | Rat | oral | - | ChemIDplus |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
0.6%
DPRA Lys %
3.9%
KeratinoSens IC50
48.885 µM
hCLAT CV75
24.2 µg/mL
LLNA EC3
10.6%
NESIL
3724 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005) | Submitted by RIFM (RIFM DB #52888); DPRA: Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868]; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]; HPPT: [103] Greif N (1967): Cutaneous safety of fragrance material as measured by the maximization test.
HRIPT Human Patch Test Studies
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 109 | 0 | 23620 | 23620 | non-sensitizer |
| HMT | - | 0 | 3724.14 | - | - |
| HMT | - | 0 | 3888 | - | - |
| HRIPT | - | 0 | 23622.05 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (limited)
LOEC: 100 µM
EU status: allowed (allergen labeling)
weak modulator
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
Brazil: Restricted (Fragrance Allergen) · max >0.001% leave-on / >0.01% rinse-off requires labeling
India: Restricted
Additional Ingredient Properties
6 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "cross_reactivity_group": "fragrance-mix-II", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "ifra_max_level_pct": "0.1", "source": "ESSCA/IVDK"}
dermal_absorption
{"molecular_weight_da": "188.3", "log_p_value": "4.2", "skin_penetration_level": "epidermis", "penetration_depth": "epidermis", "absorption_pct": "15-25", "systemic_absorption": "yes", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "10-20", "safety_margin_factor": "high", "source": "SCCS/1459/11,…
fragrance
{"cas_number": "122-40-7", "ingredient_class": "aroma_chemical", "chemical_class": "aldehyde", "odor_family": "floral", "odor_description": "Warm, spicy floral, jasmine-like", "odor_strength": "strong", "odor_tenacity_hours": "24.0", "top_note": "no", "heart_note": "yes", "base_note": "yes", "blending_factor_1_10": "8.0", "threshold_of_detection_ppb": "2.5", "molecular_weight_Da": "202.29", "boili…
pediatric_safety
{"safe_for_newborn_0_6m": "avoid", "safe_for_infant_6_12m": "caution", "safe_for_toddler_1_3y": "caution", "safe_for_child_3_12y": "caution", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "0.1", "adult_max_concentration_pct": "unlimited", "pediatric_dermal_absorption_factor": "higher", "immature_skin_barrier_risk": "moderate", "oral_ingestion_risk": "low", "eye_irritation_risk"…
regulatory
{"eu_status": "restricted", "us_status": "allowed", "eu_max_concentration": "0.001", "restricted_in": "rinse-off: >0.01%, leave-on: >0.001%", "regulation_reference": "Annex III/205"}
skin_suitability
{"oily_skin": "caution", "dry_skin": "caution", "sensitive_skin": "avoid", "combination_skin": "caution", "normal_skin": "caution", "acne_prone": "caution", "rosacea": "avoid", "eczema": "avoid", "hyperpigmentation": "caution", "aging_mature": "caution", "dehydrated": "caution", "skin_benefit_primary": "fragrance", "skin_benefit_secondary": "jasmine-scent", "mechanism_of_action": "Synthetic jasmin…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (5)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Amyl Cinnamal.
Regulatory Flags
fragrance-allergen
eu-annex-iii
fm-i
patch-test-standard
mandatory-label
eu_children_restricted
ifra_fragrance
fda_food_additive
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Amyl Cinnamal by CAS number or substance name.
Studies
4
Lowest NOAEL
0.04 mg/kg bw/day
Highest NOAEL
36 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
INCHEM_WHO_harmproj_harmproj_harmproj10
Known Synonyms
alpha- Amyl cinnamal
2-(Phenylmethylene)heptanal
2-Benzylideneheptanal
Pentylcinnamaldehyde
2-(Phenylmethylene)-heptanal
Heptanal, 2-(phenylmethylene)-
2-07-00-00310
Amyl cinnamic aldehyde
Amylcinnamal
Amylcinnamaldehyde
Amylcinnamic acid aldehyde
alpha-Amyl cinnamicaldehyde
alpha-Amyl-beta-phenylacrolein
BRN 0511292
EINECS 204-541-5
EINECS 215-565-0
FEMA No. 2061
Flomine
Heptanal, 2-benzylidene-
Jasminal
Chemical Function
Fragrance
Regulatory Lists
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe
Europe
Canada; pharmaceutical
Canada; pharmaceutical
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care
children; Europe; Personal care - general moisturizing - hand/body lotion
children; Europe; Personal care
children; Europe; Personal care
children; detected; Europe; Personal care
Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning - surface cleaner; detected; Europe
consumer_product; detected; Europe
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Amyl Cinnamal allowed in the EU?
Amyl Cinnamal EU regulatory status: restricted. Maximum allowed concentration: Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%. This is based on EU Regulation 1223/2009 and its amendments.
What does Amyl Cinnamal do in cosmetics?
Amyl Cinnamal functions as: Fragrance. It is classified as a Fragrance in our database. CAS number: 122-40-7.
What is the NOAEL for Amyl Cinnamal?
The NOAEL (No Observed Adverse Effect Level) for Amyl Cinnamal is 6 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Amyl Cinnamal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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