What is the NOAEL for Alpha-Amyl cinnamaldehyde?
Alpha-Amyl cinnamaldehyde has 66 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
Alpha-Amyl cinnamaldehyde
Also known as: alpha- Amyl cinnamal, 2-(Phenylmethylene)heptanal, 2-Benzylideneheptanal, Pentylcinnamaldehyde, 2-(Phenylmethylene)-heptanal (+15 more)
CAS 122-40-7
Alpha-Amyl cinnamaldehyde (CAS 122-40-7) is a chemical substance. Key regulatory status: 25 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
66
SOURCE
chemical inventory jurisdictions
Regulatory lists
25
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Alpha-Amyl cinnamaldehyde
CAS Number
122-40-7
DTXSID
DTXSID8029157
Molecular Formula
C14H18O
InChI Key
HMKKIXGYKWDQSV-UHFFFAOYSA-N
Monoisotopic Mass
202.135765
Synonyms
alpha- Amyl cinnamal2-(Phenylmethylene)heptanal2-BenzylideneheptanalPentylcinnamaldehyde2-(Phenylmethylene)-heptanalHeptanal, 2-(phenylmethylene)-2-07-00-00310Amyl cinnamic aldehydeAmylcinnamalAmylcinnamaldehydeAmylcinnamic acid aldehydealpha-Amyl cinnamicaldehyde
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
25 records
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning - surface cleaner; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 66 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 32.7598234957921 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 50.2937959418898 | uM | ACC | - | - | NTP_ICE_endocrine |
| range:0-0.020.02 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| range:0-0.50.5 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| 25.94 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 13.13 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 24.9 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 27.48 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 24.2 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 3.9 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.25 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 14.398 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 10.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 10.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 10.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 10.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| >2000 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| WC51CA3418 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WC51CA3418 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WC51CA3418 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WC51CA3418 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 46.77 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 51 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.57 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3724 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3888 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 23620 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.00005 | mg/m3 | LOAEL | inhalation | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.0004 | mg/m3 | LOAEL | - | Human | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.00066 | mg/g | LOAEL | - | Mouse | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.00071 | mg/g | LOAEL | - | Mouse | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.002 | mg/m3 | LOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.08 | mg/kg bw/day | LOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.19 | mg/kg bw/day | LOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.2 | mg/kg bw/day | LOAEL | - | Rat | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.5 | mg/L | LOAEL | oral | Mouse | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =1.4 | mg/L | LOAEL | - | Mouse | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =5 | mg/L | LOAEL | oral | Mouse | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =6 | mg/m3 | LOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =512 | mg/L | LOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =1036 | mg/L | LOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =30 | % | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00842 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.00000337 | mg/m3 | NOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| <0.00005 | mg/m3 | NOAEL | - | Human | INCHEM_WHO_harmproj_harmproj_harmproj10 |
| =0.0000529 | mg/m3 | NOAEL | - | - | INCHEM_WHO_harmproj_harmproj_harmproj10 |
Showing 50 of 66 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%
Category
fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Alpha-Amyl cinnamaldehyde?
Alpha-Amyl cinnamaldehyde appears on 18 regulatory/inventory lists including Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe, Europe, Canada; pharmaceutical, and 15 more. Source: EPA CPDat.
Is Alpha-Amyl cinnamaldehyde used in cosmetics?
Yes, Alpha-Amyl cinnamaldehyde is also indexed as a cosmetic ingredient under the name Amyl Cinnamal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Alpha-Amyl cinnamaldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Alpha-Amyl cinnamaldehyde used outside industrial chemicals?
Alpha-Amyl cinnamaldehyde also appears in cosmetics, cannabis databases.