Is Alpha-Methyl-Alpha-Ionone safe in cosmetics?
Alpha-Methyl-Alpha-Ionone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Alpha-Methyl-Alpha-Ionone
Also known as: Cetone, alpha-, EINECS 204-842-1, Methylionone, alpha-, 5-(2,6,6-Trimethyl-2-cyclohexenyl)-4-penten-3-one
INCI: ALPHA-METHYL-ALPHA-IONONE
Alpha-Methyl-Alpha-Ionone (CAS 127-42-4) is a cosmetic cosmetic ingredient functioning as Fragrance (Perfuming). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 127-42-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (Perfuming)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(E)-1-[(1R)-2,6,6-trimethylcyclohex-2-en-1-yl]pent-1-en-3-one
InChIKey
VPKMGDRERYMTJX-XEHSLEBBSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Alpha-Methyl-Alpha-Ionone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | - | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Alpha-Methyl-Alpha-Ionone.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Cetone, alpha-
EINECS 204-842-1
Methylionone, alpha-
5-(2,6,6-Trimethyl-2-cyclohexenyl)-4-penten-3-one
Chemical Function
Fragrance
Regulatory Lists
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Alpha-Methyl-Alpha-Ionone allowed in the EU?
Alpha-Methyl-Alpha-Ionone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Alpha-Methyl-Alpha-Ionone do in cosmetics?
Alpha-Methyl-Alpha-Ionone functions as: Fragrance (Perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 127-42-4.
Compliance Tools
Check Alpha-Methyl-Alpha-Ionone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
Fragrance (perfuming)
Alpha-Ionone
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Chemical family
Fragrance (Perfuming)
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Good
Chemical family
Fragrance ingredient
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