Is Allyl Isovalerate safe in cosmetics?
Allyl Isovalerate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Allyl Isovalerate
Also known as: Allyl 3-methylbutanoate (Prop-2-en-1-yl 3-methylbutanoate) (Allyl isovalerate), Butanoic acid, 3-methyl-, 2-propen-1-yl ester, Butanoic acid, 3-methyl-, 2-propenyl ester, Allyl isopentanoate, Allyl isovalerianate (+14 more)
INCI: ALLYL ISOVALERATE
Allyl Isovalerate (CAS 2835-39-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 31 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2835-39-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Allyl Isovalerate is classified GHS Danger (H301, H311, H226) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
prop-2-enyl 3-methylbutanoate
InChIKey
HOMAGVUCNZNWBC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA; GRAS for food use; IFRA standards apply voluntarily in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Allyl Isovalerate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Allyl Isovalerate across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
36, Sup 7, 71
Evaluation Year
1998
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
India: Restricted
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Allyl isovalerate | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 36: (1985) Allyl Compounds, Aldehydes, Epoxides and Peroxides | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Allyl isovalerate | TR-253: Carcinogenesis Studies of Allyl Isovalerate (CASRN 2835-39-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1983 ) | 09/22/82 | Clear Evidence | No Evidence | No Evidence | Clear Evidence | Under the conditions of these studies, allyl isovalerate was carcinogenic for F344/N rats and B6C3F1 mice, causing increased incidences of hematopoietic system neoplasms
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of allyl isovalerate were available. There is limited evidence in experimental animals for the carcinogenicity of allyl isovalerate. Overall evaluation: Allyl isovalerate is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
7
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALLYL 3-METHYLBUTANOATE | 1996 | 0-0.12 mg/kg bw (1990) | No safety concern at current levels of intake when used as a flavouring agent. The 1990 ADI, equivalent to 0-0.05 mg/kg allyl alcohol, for allyl heptanoate, allyl hexanoate and allyl isovalerate was maintained at the forty-sixth meeting (1996). | TRS 868-JECFA 46/28
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Allyl Isovalerate.
Regulatory Flags
fragrance-component
fda_food_additive
eu_cosing_listed
Known Synonyms
Allyl 3-methylbutanoate (Prop-2-en-1-yl 3-methylbutanoate) (Allyl isovalerate)
Butanoic acid, 3-methyl-, 2-propen-1-yl ester
Butanoic acid, 3-methyl-, 2-propenyl ester
Allyl isopentanoate
Allyl isovalerianate
Allyl 3-methylbutanoate
Allyl 3-methylbutyrate
BRN 1750520
Butyric acid, 3-methyl-, allyl ester
EINECS 220-609-7
FEMA No. 2045
3-Methylbutanoic acid, 2-propenyl ester
3-Methylbutyric acid, allyl ester
NCI-C54717
NSC 18606
2-Propenyl isopentanoate
2-Propenyl isovalerate
2-Propenyl 3-methylbutanoate
UNII-3551Z86V7T
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1887355
Frequently Asked Questions
Is Allyl Isovalerate allowed in the EU?
Allyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Allyl Isovalerate do in cosmetics?
Allyl Isovalerate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2835-39-4.
Is Allyl Isovalerate used outside cosmetics?
Allyl Isovalerate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Allyl Isovalerate have different safety status in cosmetics vs industrial chemicals?
Allyl Isovalerate is classified GHS Danger (H301, H311, H226) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Allyl Isovalerate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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