What is the NOAEL for Allyl isovalerate?
Allyl isovalerate has 20 NOAEL studies in the database. The lowest reported value is 0.12 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
IARC Group 3
Cosmetic Ingredient
Allyl isovalerate
Also known as: Allyl 3-methylbutanoate (Prop-2-en-1-yl 3-methylbutanoate) (Allyl isovalerate), Butanoic acid, 3-methyl-, 2-propen-1-yl ester, Butanoic acid, 3-methyl-, 2-propenyl ester, Allyl isopentanoate, Allyl isovalerianate (+14 more)
CAS 2835-39-4
Allyl isovalerate (CAS 2835-39-4) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.
Cross-Vertical Regulatory Divergence
Allyl isovalerate is classified GHS Danger (H301, H311, H226) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
20
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Allyl isovalerate
CAS Number
2835-39-4
DTXSID
DTXSID4039233
Molecular Formula
C8H14O2
InChI Key
HOMAGVUCNZNWBC-UHFFFAOYSA-N
Monoisotopic Mass
142.09938
Synonyms
Allyl 3-methylbutanoate (Prop-2-en-1-yl 3-methylbutanoate) (Allyl isovalerate)Butanoic acid, 3-methyl-, 2-propen-1-yl esterButanoic acid, 3-methyl-, 2-propenyl esterAllyl isopentanoateAllyl isovalerianateAllyl 3-methylbutanoateAllyl 3-methylbutyrateBRN 1750520Butyric acid, 3-methyl-, allyl esterEINECS 220-609-7FEMA No. 20453-Methylbutanoic acid, 2-propenyl ester
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 36, Sup 7, 71 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=0.12 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| 3551Z86V7T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3551Z86V7T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3551Z86V7T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3551Z86V7T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =230 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 31 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 62 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =31 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 62 | mg/kg bw/day | Top dose | Gavage | Mouse | NTP_ICE_cancer |
Showing 20 of 20 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1887355
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Allyl isovalerate?
Allyl isovalerate appears on 3 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe; Personal care; restricted. Source: EPA CPDat.
Is Allyl isovalerate a carcinogen according to IARC?
Allyl isovalerate is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Allyl isovalerate used in cosmetics?
Yes, Allyl isovalerate is also indexed as a cosmetic ingredient under the name Allyl Isovalerate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Allyl isovalerate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Allyl isovalerate have different safety status in cosmetics vs industrial chemicals?
Allyl isovalerate is classified GHS Danger (H301, H311, H226) in the chemicals database but is allowed in EU cosmetics.
Is Allyl isovalerate used outside industrial chemicals?
Allyl isovalerate also appears in cosmetics, pharmaceutical, cannabis databases.