Is Allyl Caproate safe in cosmetics?
Allyl Caproate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Allyl Caproate
Also known as: Hexanoic acid, 2-propen-1-yl ester, 4-02-00-00924, BRN 1761920, EINECS 204-642-4, FEMA No. 2032 (+4 more)
INCI: ALLYL CAPROATE (SYN. ALLYL HEXANOATE)
Allyl Caproate (CAS 123-68-2) is a cosmetic cosmetic ingredient functioning as Fragrance, Astringent, Skin Conditioning - Emollient. NOAEL 4 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 123-68-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Allyl Caproate is classified GHS Danger (H301, H311, H315, H319, H331, H400, H410, H411) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance, Astringent, Skin Conditioning - Emollient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
prop-2-enyl hexanoate
InChIKey
RCSBILYQLVXLJG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted in cosmetics; FEMA GRAS (No. 2032) for flavoring
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Allyl Caproate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Allyl Caproate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 65 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 125 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Allyl Caproate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
India: Restricted
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
3
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALLYL CAPROATE | 1996 | 0-0.13 mg/kg bw (1990) | No safety concern at current levels of intake when used as a flavouring agent. The 1990 ADI, equivalent to 0-0.05 mg/kg allyl alcohol, for allyl heptanoate, allyl hexanoate and allyl isovalerate, was maintained at the forty-sixth meeting (1996). | TRS 868-JECFA 46/28
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Astringent
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (4)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Allyl Caproate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Allyl Caproate by CAS number or substance name.
Studies
4
Lowest NOAEL
65 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
COSMOS_DB
Known Synonyms
Hexanoic acid, 2-propen-1-yl ester
4-02-00-00924
BRN 1761920
EINECS 204-642-4
FEMA No. 2032
NSC 20962
2-Propenyl n-hexanoate
Allylester kyseliny kapronove
UNII-3VH84A363D
Chemical Function
Fragrance
Softener and conditioner
Astringent
Deodorizer
Flavouring and nutrient
Regulatory Lists
Europe; Personal care; restricted
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ALLYL HEXANOATE
ChEMBL ID
CHEMBL2229585
Frequently Asked Questions
Is Allyl Caproate allowed in the EU?
Allyl Caproate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Allyl Caproate do in cosmetics?
Allyl Caproate functions as: Fragrance, Astringent, Skin Conditioning - Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 123-68-2.
What is the NOAEL for Allyl Caproate?
The NOAEL (No Observed Adverse Effect Level) for Allyl Caproate is 65 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is Allyl Caproate used outside cosmetics?
Allyl Caproate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Allyl Caproate have different safety status in cosmetics vs industrial chemicals?
Allyl Caproate is classified GHS Danger (H301, H311, H315, H319, H331, H400, H410, H411) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Allyl Caproate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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