NOAEL Studies Cosmetic Ingredient

Allyl Caproate NOAEL Studies

INCI: ALLYL CAPROATE (SYN. ALLYL HEXANOATE)

CAS: 123-68-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 65 mg/kg bw/day rat oral 126 day Subchronic PAFA; FOOD COSMET TOXICOL 5:141-157
COSMOS_DB NOAEL 12 mg/kg bw/day rat oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 15 mg/kg bw/day rat oral 126 day Subchronic PAFA; FOOD COSMET TOXICOL 5:141-157
COSMOS_DB NOAEL 65 mg/kg bw/day rat oral 126 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral 196 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 125 mg/kg bw/day rat oral 365 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 250 mg/kg bw/day rat oral 730 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =218 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_2073; row=3243; data_type=In Vivo; mixture=Chemical; chemical_name=Allyl hexanoate; preferred_name=Allyl hexanoate; dtxsid=DTXSID1047653; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047653; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4572; Record_ID=skin_sensitization_invivo_1098; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047653; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90020-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047653
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4571; Record_ID=skin_sensitization_invivo_1098; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047653; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90020-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047653
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4576; Record_ID=skin_sensitization_invivo_1098; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047653; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90020-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047653
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =75 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/3/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID:15801431:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44990a90927da26979683225e6111a27
ToxValDB_ECHA_IUCLID LOAEL =35 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c287d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/6/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID:15850596:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7c97aebea5edaad9139ba511c946fde6
ToxValDB_ECHA_IUCLID LOAEL =65 mg/kg bw/day Rat oral chronic; 18 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c287f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/6/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833207_15850964:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_95bd060c7dcb14f719d427a4bd778101
ToxValDB_ECHA_IUCLID LOEL =12 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c288d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/6/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID:15850598:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_55ecffd3e510b4b8e4bf7941757009fc
ToxValDB_ECHA_IUCLID NOAEL >195 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2881; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/6/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847302_15847952:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_663df2bfa3e2fde570382365816331ca
ToxValDB_ECHA_IUCLID NOAEL >214 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2881; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/6/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847302_15847952:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1376c51c5bd95e0ebd5e1f129dbfbd2c
ToxValDB_ECHA_IUCLID NOEL =15 mg/kg bw/day Rat oral chronic; 18 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c287f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/6/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833207_15850964:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f8ed93b3dc3e4c03a39ca348ea80ebc
ToxValDB_ECHA_IUCLID NOEL =78 mg/kg bw/day Rat oral chronic; 28 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2889; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12389/7/6/2?documentUUID=9d9e59f3-2596-4889-a15a-aee9f3cc3d53; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=ECHA IUCLID:15850597:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5e9f90c5b70c002591fdb949a67e6696
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LEL =50 mg/kg bw/day Chicken oral subchronic; 36 days subchronic LONG_REF=EFSA FEEDAP (2020). Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species. doi:10.2903/j.efsa.2020.6338.; TITLE=Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2020.6338; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15622623:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ede026dfa6d3f412bbb7877fd0f14cfd
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =15 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629589:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0e18f1e0ba4f9c3a97cf6e51b765785
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=0.13 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af91ce4b0d99f5a8777e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/974; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=WHO JECFA ADI:15715280:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dfb2b18c186b027430df84f8544aa994
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3VH84A363D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3VH84A363D"}
openFDA substances FDA UNII substance identifier 3VH84A363D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3VH84A363D"}
openFDA substances FDA UNII substance identifier 3VH84A363D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3VH84A363D"}
openFDA substances FDA UNII substance identifier 3VH84A363D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3VH84A363D"}