Is Acetylcedrene safe in cosmetics?
Acetylcedrene has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Acetylcedrene
Also known as: 9-Acetyl-8-cedrene, Acetyl-alpha-cedrene, Methyl cedryl ketone, Ethanone, 1-[(3R,3aR,7R,8aS)-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl]-, Ethanone, 1-[(3R,3aR,7R,8aS)-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl]- (+12 more)
INCI: ACETYLCEDRENE
Acetylcedrene (CAS 32388-55-9) is a cosmetic cosmetic ingredient functioning as Perfuming (woody/amber fragrance note). Reported NOAEL =50 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 32388-55-9 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming (woody/amber fragrance note)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-[(1R,2R,5S,7R)-2,6,6,8-tetramethyl-9-tricyclo[5.3.1.01,5]undec-8-enyl]ethanone
InChIKey
YBUIAJZFOGJGLJ-SWRJLBSHSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not restricted by FDA. California's Cosmetic Fragrance and Flavor Ingredient Right to Know Act (2020) requires disclosure at the same EU thresholds
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetylcedrene.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Acetylcedrene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =80 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | dermal | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
3100 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [518] RIFM (1972): RIFM report number 1804, May 2, unpublished.
HRIPT Human Patch Test Studies
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 101 | 0 | 35433 | 35433 | non-sensitizer |
| HMT | - | 0 | 19440 | - | - |
| HRIPT | - | 0 | 3100.01 | - | - |
| HRIPT | - | 0 | 35433.07 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Acetylcedrene.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acetylcedrene by CAS number or substance name.
Studies
4
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
9-Acetyl-8-cedrene
Acetyl-alpha-cedrene
Methyl cedryl ketone
Ethanone, 1-[(3R,3aR,7R,8aS)-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl]-
Ethanone, 1-[(3R,3aR,7R,8aS)-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl]-
Ethanone, 1-(2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl)-, [3R-(3α,3aβ,7β,8aα)]-
1-[(3R,3aR,7R,8aS)-2,3,4,7,8,8a-Hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl]ethanone
1H-3a,7-Methanoazulene, ethanone deriv.
1-((3R,3AR,7R,8aS)-3,6,8,8-tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulen-5-yl)ethan-1-one
1-[(3R,3aR,7R,8aS)-3,6,8,8-Tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulen-5-yl]ethan-1-one
Acetyl-α-cedrene
[3R-(3α,3aβ,7β,8aα)]-1-(2,3,4,7,8,8a-Hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl)ethan-1-one
CEDRENE, 9-ACETYL-
1-(Cedr-8-en-9-yl)ethanone
1-Cedr-8-en-9-ylethanone
EINECS 251-020-3
Lixetone
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184309
Frequently Asked Questions
Is Acetylcedrene allowed in the EU?
Acetylcedrene EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetylcedrene do in cosmetics?
Acetylcedrene functions as: Perfuming (woody/amber fragrance note). It is classified as a cosmetic ingredient in our database. CAS number: 32388-55-9.
What is the NOAEL for Acetylcedrene?
The NOAEL (No Observed Adverse Effect Level) for Acetylcedrene is =50 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 4 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Acetylcedrene used outside cosmetics?
Acetylcedrene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acetylcedrene compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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