NOAEL Studies
Cosmetic Ingredient
Acetylcedrene NOAEL Studies
INCI: ACETYLCEDRENE
CAS: 32388-55-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 13.9656498184324 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4596; RecordID=ERPathway2016_271; DatasetName=ERPathway2016; DTXSID=DTXSID4029353; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=13.9656498184324; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_endocrine | ACC | 10.4219672132238 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4597; RecordID=ERPathway2016_271; DatasetName=ERPathway2016; DTXSID=DTXSID4029353; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=10.4219672132238; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4592; RecordID=ARPathway2016_1139; DatasetName=ARPathway2016; DTXSID=DTXSID4029353; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_endocrine | Model Score | 0.0562 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=4598; RecordID=ERPathway2016_271; DatasetName=ERPathway2016; DTXSID=DTXSID4029353; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0562; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
NTP_ICE_skin_sensitization 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | EC3 | 13.9 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13269; Record_ID=skin_sensitization_invivo_3351; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=LLNA; Endpoint=EC3; Response=13.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | EC3 | 13.9 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13269; Record_ID=skin_sensitization_invivo_3351; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=LLNA; Endpoint=EC3; Response=13.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | EC3 | 13.9 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13269; Record_ID=skin_sensitization_invivo_3351; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=LLNA; Endpoint=EC3; Response=13.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | EC3 | 13.9 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13269; Record_ID=skin_sensitization_invivo_3351; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=LLNA; Endpoint=EC3; Response=13.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6714; Record_ID=skin_sensitization_invivo_1538; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2013; 24246175; 10.1016/j.fct.2013.09.033|Scognamiglio et al. 2013; 23907023; 10.1016/j.fct.2013.07.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 19440 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6712; Record_ID=skin_sensitization_invivo_1538; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=19440; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2013; 24246175; 10.1016/j.fct.2013.09.033|Scognamiglio et al. 2013; 23907023; 10.1016/j.fct.2013.07.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 3100 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6720; Record_ID=skin_sensitization_invivo_1540; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3100; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2013; 24246175; 10.1016/j.fct.2013.09.033|Scognamiglio et al. 2013; 23907023; 10.1016/j.fct.2013.07.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 35430 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6729; Record_ID=skin_sensitization_invivo_1542; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=35430; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2013; 24246175; 10.1016/j.fct.2013.09.033|Scognamiglio et al. 2013; 23907023; 10.1016/j.fct.2013.07.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6718; Record_ID=skin_sensitization_invivo_1538; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4029353; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2013; 24246175; 10.1016/j.fct.2013.09.033|Scognamiglio et al. 2013; 23907023; 10.1016/j.fct.2013.07.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029353 |
ToxValDB_ECHA_IUCLID 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd688; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12524/7/9/3?documentUUID=ef751678-b9cd-4fde-9d06-5ea3814b6a33; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15821546:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11e094c139ccf55bd451a607ab2a3861 |
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd688; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12524/7/9/3?documentUUID=ef751678-b9cd-4fde-9d06-5ea3814b6a33; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15822846:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9df5b0dd2cc634f82236bdb43cf9324 |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d6fe4b096bca8775bd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12524/7/6/4?documentUUID=ef751678-b9cd-4fde-9d06-5ea3814b6a33; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15826163:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5b2dab3f7e942ac514b137207ca6600 |
| ToxValDB_ECHA_IUCLID | NOAEL | =80 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae13e4b0a7c65d1c7722; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12524/7/6/2?documentUUID=ef751678-b9cd-4fde-9d06-5ea3814b6a33; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=kidney: haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=multiple|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15839943:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fcf5f7627dedf5970138fb84d9a647c |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1.17 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632491:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7fd3cb7189b2dea1fd045628e435702b |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | X6I62755AK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X6I62755AK"} |
| openFDA substances | FDA UNII substance identifier | X6I62755AK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X6I62755AK"} |
| openFDA substances | FDA UNII substance identifier | X6I62755AK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X6I62755AK"} |
| openFDA substances | FDA UNII substance identifier | X6I62755AK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X6I62755AK"} |