Is Acetyl Octapeptide-3 safe in cosmetics?
Acetyl Octapeptide-3 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Acetyl Octapeptide-3
Also known as: UNII-8K14HJF88S, Acetyl-glu-glu-met-gln-arg-arg-ala-asp-amide, Ac-glu-glu-met-gln-arg-arg-ala-asp-nh2
INCI: ACETYL OCTAPEPTIDE-3
Acetyl Octapeptide-3 (CAS 868844-74-0) is a cosmetic active ingredient functioning as Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 868844-74-0 →
Auto-generated CPSR Part A draft with source citations
Function
Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue that targets the SNARE complex at the neuromuscular junction. Disrupts vesicle fusion with the neuronal membrane by competing for SNAP-25 binding sites, thereby inhibiting acetylcholine exocytosis and reducing muscle contraction at expression line sites.
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
InChIKey
QGGBBQJHVCVVKM-XOBYPWAZSA-N
SMILES
CC(C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=C)C(CCC(=O)O)NC(=O)C
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA or CIR restriction. No pre-market approval required under MoCRA for cosmetic peptides. CIR has not specifically reviewed Acetyl Octapeptide-3 as of this report.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Octapeptide-3.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
6 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-wrinkle, expression-lines", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "15-25", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int …
anti_pollution
{"cas_number": "868844-74-0", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
concentration
{"min_concentration_pct": "0.05", "max_concentration_pct": "1.0", "typical_concentration_pct": "0.5", "product_type": "Serum", "function_at_concentration": "Wrinkle reduction", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "luxury", "estimated_cost_per_kg_usd_low": "11000", "estimated_cost_per_kg_usd_high": "17000", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global (synthetic)", "bulk_discount_threshold_kg": "1", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "A…
peptide
{"cas_number": "868844-74-0", "trade_name": "SNAP-8", "peptide_sequence_amino_acids": "Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp", "peptide_length_residues": "8", "molecular_weight_daltons": "1075.2", "peptide_class": "neurotransmitter_inhibitor", "mechanism_of_action": "Enhanced SNARE complex inhibition, more potent than Argireline", "target_protein_or_receptor": "SNAP-25/SNARE complex", "biomimetic_of"…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Alternative to Argireline", "formulation_note": "Similar stability profile", "source": "Formulation literature"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Octapeptide-3.
Regulatory Flags
neurotransmitter-inhibitor
snare-complex
snap-25-analogue
snap-8
acetylcholine-inhibitor
Known Synonyms
UNII-8K14HJF88S
Acetyl-glu-glu-met-gln-arg-arg-ala-asp-amide
Ac-glu-glu-met-gln-arg-arg-ala-asp-nh2
Chemical Function
Humectant
Softener and conditioner
Frequently Asked Questions
Is Acetyl Octapeptide-3 allowed in the EU?
Acetyl Octapeptide-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Octapeptide-3 do in cosmetics?
Acetyl Octapeptide-3 functions as: Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue that targets the SNARE complex at the neuromuscular junction. Disrupts vesicle fusion with the neuronal membrane by competing for SNAP-25 binding sites, thereby inhibiting acetylcholine exocytosis and reducing muscle contraction at expression line sites.. It is classified as a Active Ingredient in our database. CAS number: 868844-74-0.
Compliance Tools
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MoS Calculator
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Chemical family
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Chemical family
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ACETALDEHYDE
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Fragrance
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