Is OCTAPEPTIDE-1 safe in cosmetics?
OCTAPEPTIDE-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
OCTAPEPTIDE-1
Also known as: UNII-8K14HJF88S, Acetyl-glu-glu-met-gln-arg-arg-ala-asp-amide, Ac-glu-glu-met-gln-arg-arg-ala-asp-nh2
OCTAPEPTIDE-1 (CAS 868844-74-0) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 868844-74-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
InChIKey
QGGBBQJHVCVVKM-XOBYPWAZSA-N
SMILES
CC(C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=C)C(CCC(=O)O)NC(=O)C
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
**Allowed** — no specific prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-wrinkle, firming", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-20", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for OCTAPEPTIDE-1.
Regulatory Flags
cosing-sourced
eu-permitted
no-cas-assigned
skin-conditioning
needs-enrichment
Known Synonyms
UNII-8K14HJF88S
Acetyl-glu-glu-met-gln-arg-arg-ala-asp-amide
Ac-glu-glu-met-gln-arg-arg-ala-asp-nh2
Chemical Function
Humectant
Softener and conditioner
Frequently Asked Questions
Is OCTAPEPTIDE-1 allowed in the EU?
OCTAPEPTIDE-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTAPEPTIDE-1 do in cosmetics?
OCTAPEPTIDE-1 functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 868844-74-0.
Compliance Tools
Check OCTAPEPTIDE-1 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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