Is Acetyl Hexapeptide-1 safe in cosmetics?
Acetyl Hexapeptide-1 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Acetyl Hexapeptide-1
INCI: ACETYL HEXAPEPTIDE-1
Acetyl Hexapeptide-1 (CAS 448944-47-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, melanin stimulator, photo-protection enhancer. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 448944-47-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, melanin stimulator, photo-protection enhancer
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-2-acetamido-N-[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]hexanamide
InChIKey
WPIQUSRULDNCKM-IFSWANACSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not classified as a sunscreen active by the FDA; no GRAS classification applies. No specific MoCRA restrictions or monograph entries. Not reviewed by the CIR Expert Panel as of February 2026. Claims related to stimulating melanocyte activity or photo-protection via MC1-R activation may trigger FDA drug classification if marketed as structure/function claims in the US.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Hexapeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
self_tanning
{"cas_number": "proprietary", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "72.0", "full_color_development_hours": "240", "color_duration_days": "14", "color_depth": "light", "undertone": "natural", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_releas…
skin_brightening
{"cas_number": "448944-47-6", "mechanism_of_action": "Melanocortin receptor modulation", "melanogenesis_pathway_target": "Melanocortin receptors", "tyrosinase_inhibition_ic50_um": "Receptor modulator", "tyrosinase_inhibition_vs_kojic_acid": "Receptor pathway", "melanosome_transfer_inhibitor": "No", "melanin_oxidation_reducer": "Partial", "endothelin_pathway_blocker": "No", "alpha_msh_antagonist": …
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Hexapeptide-1.
Regulatory Flags
no-sccs-opinion
no-cir-review
data-gap
melanogenesis-stimulator
mc1r-agonist
drug-claim-risk
high-molecular-weight
no-mos-calculated
no-sensitization-data
no-dermal-absorption-data
Frequently Asked Questions
Is Acetyl Hexapeptide-1 allowed in the EU?
Acetyl Hexapeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Hexapeptide-1 do in cosmetics?
Acetyl Hexapeptide-1 functions as: Skin conditioning agent, melanin stimulator, photo-protection enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 448944-47-6.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Fragrance
ACETOBACTER FERMENT EXTRACT FILTRATE
Good
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Deodorant
ACETOBACTER/ASPERGILLUS/LACTOBACILLUS/LEUCONOSTOC/PEDIOCOCCUS/SACCHAROMYCES/ZYGOSACCHAROMYCES/CITRUS UNSHIU FRUIT/CITRUS JAPONICA FRUIT/CITRUS JUNOS FRUIT/ APPLE FRUIT/BANANA FRUIT/PAPAYA FRUIT/ PYRUS SEROTINA FRUIT/ DIOSPYROS KAKI FRUIT/WATERMELON FRUIT/PEACH FRUIT/ PRUNUS MUME FRUIT/FIG FRUIT/CHAENOMELES SINENSIS FRUIT/ERIOBOTRYA JAPONICA FRUIT/APRICOT FRUIT/ ZIZYPHUS JUJUBA FRUIT/CUCURBITA MAXIMA FRUIT/CASTANEA CRENATA FRUIT/VITIS COIGNETIAE FRUIT/RASPBERRY FRUIT/MOMORDICA GROSVENORII FRUIT/LYCIUM CHINENSE FRUIT/GLYCINE MAX SEED/PHASEOLUS ANGULARIS SEED/CANAVALIA ENSIFORMIS SEED/RICE SEED/HORDEUM VULGARE SEED/COIX LACRYMA-JOBI MA-YUEN SEED/ECHINOCHLOA CRUS-GALLI SEED/SETARIA ITALICA SEED/MILLET SEED/HEMEROCALLIS FULVA FLOWER/CABBAGE LEAF/STEM/MORUS BOMBYCIS LEAF/PERILLA FRUTESCENS LEAF/IPOMOEA BATATAS ROOT/COLOCASIA ANTIQUORUM TUBER/DIOSCOREA BATATAS RHIZOME/IRIDEA LAMINARIOIDES/LAMINARIA JAPONICA/NEMACYSTUS DECIPIENS/UNDARIA PINNATIFIDA/RADISH ROOT/TURNIP ROOT/CARROT ROOT/ARCTIUM LAPPA ROOT/NELUMBO NUCIFERA RHIZOME/ONION BULB/LILIUM AURATUM BULB/LICORICE ROOT/SAGITTARIA TRIFOLIA ROOT/SESAME SEED/GINKGO BILOBA SEED/JUGLANS SUBCORDIFORMIS FRUIT/PANAX GINSENG SEED/ACTINIDIA POLYGAMA FRUIT/HYDNUM ERINACEUM FRUITING BODY/GRIFOLA FRONDOSA FRUITING BODY/PRUNUS SALICINA FRUIT/AKEBIA QUINATA FRUIT/CRATAEGUS CUNEATA FRUIT/CORNUS OFFICINALIS FRUIT/NEPHELIUM LONGANA FRUIT/HOUTTUYNIA CORDATA/ARTEMISIA PRINCEPS/SASA VEITCHII LEAF/GLECHOMA HEDERACEA/CHAMOMILLA RECUTITA FLOWER/EQUISETUM ARVENSE/CASSIA OBTUSIFOLIA SEED/TARAXACUM OFFICINALE/ISODON JAPONICUS/SAFFLOWER FLOWER/PLANTAGO ASIATICA/SMALLANTHUS SONCHIFOLIUS ROOT/GARLIC BULB/GINGER RHIZOME/BEET RHIZOME/POLYGONUM ODORATUM RHIZOME/TURMERIC RHIZOME/ACANTHOPANAX SIEBOLDIANUS ROOT/PINUS KORAIENSIS SEED/LENTINUS EDODES FRUITING BODY/AURICULARIA AURICULA/VITIS LABRUSCA FRUIT/HELIANTHUS TUBEROSUS TUBER FERMENT EXTRACT
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Skin Conditioning
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