Is 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE safe in cosmetics?
4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE
Also known as: Vanillyl isobutyrate, Propanoic acid, 2-methyl-, 4-formyl-2-methoxyphenyl ester, EINECS 243-956-6, FEMA No. 3754, 4-Formyl-2-methoxyphenyl 2-methylpropanoate (+7 more)
4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE (CAS 20665-85-4) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 20665-85-4 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
243-956-6
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 109 | 0 | 590 | 590 | non-sensitizer |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE by CAS number or substance name.
Studies
4
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Vanillyl isobutyrate
Propanoic acid, 2-methyl-, 4-formyl-2-methoxyphenyl ester
EINECS 243-956-6
FEMA No. 3754
4-Formyl-2-methoxyphenyl 2-methylpropanoate
4-Hydroxy-m-anisaldehyde isobutyrate
4-Hydroxy-m-anisaldehyde 2-methylpropionate
4-Hydroxy-3-methoxybenzaldehyde isobutyrate
4-Hydroxy-3-methoxybenzaldehyde 2-methylpropionate
Isobutyric acid, ester with vanillin
3-Methoxy-4-isobutyrylbenzaldehyde
UNII-C55654RCNR
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188782
Frequently Asked Questions
Is 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE allowed in the EU?
4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE do in cosmetics?
4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 20665-85-4.
What is the NOAEL for 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE?
The NOAEL (No Observed Adverse Effect Level) for 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE is =1000 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE used outside cosmetics?
4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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