What is the NOAEL for 4-Formyl-2-methoxyphenyl isobutyrate?
4-Formyl-2-methoxyphenyl isobutyrate has 5 NOAEL studies in the database. The lowest reported value is C55654RCNR UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Formyl-2-methoxyphenyl isobutyrate
Also known as: Vanillyl isobutyrate, Propanoic acid, 2-methyl-, 4-formyl-2-methoxyphenyl ester, EINECS 243-956-6, FEMA No. 3754, 4-Formyl-2-methoxyphenyl 2-methylpropanoate (+7 more)
CAS 20665-85-4
4-Formyl-2-methoxyphenyl isobutyrate (CAS 20665-85-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) →
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
4-Formyl-2-methoxyphenyl isobutyrate
CAS Number
20665-85-4
DTXSID
DTXSID9047201
Molecular Formula
C12H14O4
InChI Key
BGKAKRUFBSTALK-UHFFFAOYSA-N
Monoisotopic Mass
222.089209
Synonyms
Vanillyl isobutyratePropanoic acid, 2-methyl-, 4-formyl-2-methoxyphenyl esterEINECS 243-956-6FEMA No. 37544-Formyl-2-methoxyphenyl 2-methylpropanoate4-Hydroxy-m-anisaldehyde isobutyrate4-Hydroxy-m-anisaldehyde 2-methylpropionate4-Hydroxy-3-methoxybenzaldehyde isobutyrate4-Hydroxy-3-methoxybenzaldehyde 2-methylpropionateIsobutyric acid, ester with vanillin3-Methoxy-4-isobutyrylbenzaldehydeUNII-C55654RCNR
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
20 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| C55654RCNR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C55654RCNR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C55654RCNR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C55654RCNR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-formyl-2-methoxyphenyl isobutyrate | 243-956-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188782
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Formyl-2-methoxyphenyl isobutyrate?
4-Formyl-2-methoxyphenyl isobutyrate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 4-Formyl-2-methoxyphenyl isobutyrate used in cosmetics?
Yes, 4-Formyl-2-methoxyphenyl isobutyrate is also indexed as a cosmetic ingredient under the name 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Formyl-2-methoxyphenyl isobutyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Formyl-2-methoxyphenyl isobutyrate used outside industrial chemicals?
4-Formyl-2-methoxyphenyl isobutyrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.