Is 2,6-Dimethylheptanol safe in cosmetics?
2,6-Dimethylheptanol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
2,6-Dimethylheptanol
Also known as: 2-Heptanol, 2,6-dimethyl-, 2-01-00-00457, BRN 1733525, 2,6-Dimethylheptan-2-ol, Dimetol (+4 more)
INCI: 2,6-DIMETHYLHEPTANOL
2,6-Dimethylheptanol (CAS 13254-34-7) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming). Reported NOAEL =10000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 13254-34-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (perfuming)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,6-dimethylheptan-2-ol
InChIKey
HGDVHRITTGWMJK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not individually regulated; fragrance exemption applies
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,6-Dimethylheptanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 2,6-Dimethylheptanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
3100 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [192] Kligman AM (1976): Report to RIFM, 4 November, unpublished.
HRIPT Human Patch Test Studies
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
| HRIPT | - | 0 | - | - | - |
| HRIPT | - | 0 | 3100.01 | - | - |
| HRIPT | - | 0 | 3100.01 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for 2,6-Dimethylheptanol.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2,6-Dimethylheptanol by CAS number or substance name.
Studies
1
Lowest NOAEL
10000 mg/kg bw/day
Highest NOAEL
10000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Heptanol, 2,6-dimethyl-
2-01-00-00457
BRN 1733525
2,6-Dimethylheptan-2-ol
Dimetol
EINECS 236-244-1
Freesiol
Lolitol
UNII-991142090Z
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Personal care
IFRA Transparency
Europe
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187118
Frequently Asked Questions
Is 2,6-Dimethylheptanol allowed in the EU?
2,6-Dimethylheptanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Dimethylheptanol do in cosmetics?
2,6-Dimethylheptanol functions as: Fragrance (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 13254-34-7.
What is the NOAEL for 2,6-Dimethylheptanol?
The NOAEL (No Observed Adverse Effect Level) for 2,6-Dimethylheptanol is =10000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 2,6-Dimethylheptanol used outside cosmetics?
2,6-Dimethylheptanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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