NOAEL Studies
Cosmetic Ingredient
2,6-Dimethylheptanol NOAEL Studies
INCI: 2,6-DIMETHYLHEPTANOL
CAS: 13254-34-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =6800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2297; row=10824; data_type=In Vivo; mixture=Chemical; chemical_name=2,6-Dimethyl-2-heptanol; preferred_name=2,6-Dimethyl-2-heptanol; dtxsid=DTXSID6041424; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041424; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2038; RecordID=ARPathway2016_786; DatasetName=ARPathway2016; DTXSID=DTXSID6041424; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041424 |
NTP_ICE_skin_sensitization 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4727; Record_ID=skin_sensitization_invivo_1136; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6041424; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2010; 20659630; 10.1016/j.fct.2010.05.046|Belsito et al. 2010; 20141871; 10.1016/j.fct.2009.11.007|McGinty et al. 2010; 20659632; 10.1016/j.fct.2010.05.041; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041424 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 3100 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4725; Record_ID=skin_sensitization_invivo_1136; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6041424; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3100; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2010; 20659630; 10.1016/j.fct.2010.05.046|Belsito et al. 2010; 20141871; 10.1016/j.fct.2009.11.007|McGinty et al. 2010; 20659632; 10.1016/j.fct.2010.05.041; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041424 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 6750 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4736; Record_ID=skin_sensitization_invivo_1139; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6041424; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90220-F; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041424 |
| NTP_ICE_skin_sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4724; Record_ID=skin_sensitization_invivo_1135; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6041424; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1969; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2010; 20659630; 10.1016/j.fct.2010.05.046|Belsito et al. 2010; 20141871; 10.1016/j.fct.2009.11.007|McGinty et al. 2010; 20659632; 10.1016/j.fct.2010.05.041; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041424 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4731; Record_ID=skin_sensitization_invivo_1136; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6041424; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2010; 20659630; 10.1016/j.fct.2010.05.046|Belsito et al. 2010; 20141871; 10.1016/j.fct.2009.11.007|McGinty et al. 2010; 20659632; 10.1016/j.fct.2010.05.041; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041424 |
ToxValDB_ECHA_IUCLID 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =3000 | ppm | Rat | oral | short-term; 29 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca69e4b0a7c65d221b43; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19403/7/6/2?documentUUID=3bb7f593-515e-4597-be3f-a901b68ac2b5; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15842902:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb679db7fcb10e6bdb1b4e68eb830c3c |
| ToxValDB_ECHA_IUCLID | NOAEL | =10000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b65d4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19403/7/9/2?documentUUID=3bb7f593-515e-4597-be3f-a901b68ac2b5; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=F1: clinical signs|F1: mortality|F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15859219:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f5dd76e2bc6ca7d830a12938eb66cc8 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =10.05 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631403_15631404:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_862f0a1d4e78fd956c6e964386a6e0e7 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =4.02 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631403_15631404:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0af0e93064458c8cdad369ccc6f91671 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 991142090Z | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"991142090Z"} |
| openFDA substances | FDA UNII substance identifier | 991142090Z | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"991142090Z"} |
| openFDA substances | FDA UNII substance identifier | 991142090Z | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"991142090Z"} |
| openFDA substances | FDA UNII substance identifier | 991142090Z | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"991142090Z"} |