Is 2-Sec-Butylcyclohexanone safe in cosmetics?
2-Sec-Butylcyclohexanone has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted.
Good
Cosmetic Ingredient
2-Sec-Butylcyclohexanone
Also known as: 2-sec.-Butylcyclohexanone (Cyclohexanone, 2-(1-methylpropyl)-), Cyclohexanone, 2-(1-methylpropyl)-, BRN 1859137, Butylcyclohexanone, O-sec-, Cyclohexanone, 2-sec-butyl- (+5 more)
INCI: 2-SEC-BUTYLCYCLOHEXANONE
2-Sec-Butylcyclohexanone (CAS 14765-30-1) is a cosmetic cosmetic ingredient functioning as Perfuming (fragrance). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 14765-30-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Sec-Butylcyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
Function
Perfuming (fragrance)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-butan-2-ylcyclohexan-1-one
InChIKey
RQXTZKGDMNIWJF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — listed on EAFUS (FDA); no specific cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Sec-Butylcyclohexanone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1109
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-sec-BUTYLCYCLOHEXANONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/95, 111 | FAS 50-JECFA 59/331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
FRESKOMENTHE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/95, 111 | FAS 50-JECFA 59/331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2-Sec-Butylcyclohexanone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
2-sec.-Butylcyclohexanone (Cyclohexanone, 2-(1-methylpropyl)-)
Cyclohexanone, 2-(1-methylpropyl)-
BRN 1859137
Butylcyclohexanone, O-sec-
Cyclohexanone, 2-sec-butyl-
EINECS 238-830-2
FEMA No. 3261
2-(1-Methylpropyl)cyclohexanone
NSC 21146
UNII-5WA6R1KL5J
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 2-Sec-Butylcyclohexanone allowed in the EU?
2-Sec-Butylcyclohexanone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Sec-Butylcyclohexanone do in cosmetics?
2-Sec-Butylcyclohexanone functions as: Perfuming (fragrance). It is classified as a cosmetic ingredient in our database. CAS number: 14765-30-1.
Is 2-Sec-Butylcyclohexanone used outside cosmetics?
2-Sec-Butylcyclohexanone also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Sec-Butylcyclohexanone have different safety status in cosmetics vs industrial chemicals?
2-Sec-Butylcyclohexanone is prohibited in EU cosmetics but has active industrial GHS classifications.
Compliance Tools
Check 2-Sec-Butylcyclohexanone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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