What is the NOAEL for 2-sec-Butylcyclohexan-1-one?
2-sec-Butylcyclohexan-1-one has 12 NOAEL studies in the database. The lowest reported value is 3.55 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-sec-Butylcyclohexan-1-one
Also known as: 2-sec.-Butylcyclohexanone (Cyclohexanone, 2-(1-methylpropyl)-), 2-sec-Butylcyclohexanone, Cyclohexanone, 2-(1-methylpropyl)-, BRN 1859137, Butylcyclohexanone, O-sec- (+6 more)
CAS 14765-30-1
2-sec-Butylcyclohexan-1-one (CAS 14765-30-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-sec-Butylcyclohexan-1-one is prohibited in EU cosmetics but has active industrial GHS classifications.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
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noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
17 fields
Name
2-sec-Butylcyclohexan-1-one
CAS Number
14765-30-1
DTXSID
DTXSID4041818
Molecular Formula
C10H18O
InChI Key
RQXTZKGDMNIWJF-UHFFFAOYSA-N
Monoisotopic Mass
154.135765
Synonyms
2-sec.-Butylcyclohexanone (Cyclohexanone, 2-(1-methylpropyl)-)2-sec-ButylcyclohexanoneCyclohexanone, 2-(1-methylpropyl)-BRN 1859137Butylcyclohexanone, O-sec-Cyclohexanone, 2-sec-butyl-EINECS 238-830-2FEMA No. 32612-(1-Methylpropyl)cyclohexanoneNSC 21146UNII-5WA6R1KL5J
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =8.87 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =3.55 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5WA6R1KL5J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5WA6R1KL5J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5WA6R1KL5J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5WA6R1KL5J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =2000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-sec-butylcyclohexan-1-one | 238-830-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-sec-Butylcyclohexan-1-one?
2-sec-Butylcyclohexan-1-one appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-sec-Butylcyclohexan-1-one used in cosmetics?
Yes, 2-sec-Butylcyclohexan-1-one is also indexed as a cosmetic ingredient under the name 2-Sec-Butylcyclohexanone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-sec-Butylcyclohexan-1-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-sec-Butylcyclohexan-1-one have different safety status in cosmetics vs industrial chemicals?
2-sec-Butylcyclohexan-1-one is prohibited in EU cosmetics but has active industrial GHS classifications.
Is 2-sec-Butylcyclohexan-1-one used outside industrial chemicals?
2-sec-Butylcyclohexan-1-one also appears in cosmetics, food safety, cannabis databases.