Is 2-Hydroxypropyl Acrylate safe in cosmetics?
2-Hydroxypropyl Acrylate has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
2-Hydroxypropyl Acrylate
Also known as: beta-Hydroxypropyl acrylate, 1,2-Propanediol, 1-acrylate, 2-Propenoic acid, 2-hydroxypropyl ester, Acrylic acid, 2-hydroxypropyl ester, β-Hydroxypropyl acrylate (+12 more)
INCI: HYDROXYPROPYL ACRYLATE
2-Hydroxypropyl Acrylate (CAS 999-61-1) is a cosmetic cosmetic ingredient functioning as Film forming for nail products and adhesives. EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 999-61-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Hydroxypropyl Acrylate is classified GHS Danger (H301, H311, H314, H317, H331, H302, H310, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film forming for nail products and adhesives
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-hydroxypropyl prop-2-enoate
InChIKey
GWZMWHWAWHPNHN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; acrylates copolymers reviewed by CIR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Hydroxypropyl Acrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
CorrSkullToxicCancerHealth haz
Hazard Statements
Combustible liquid Toxic if swallowed Fatal in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause damage to respiratory tract if inhaled May be harmful if swallowed and enters airways Toxic to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. See Notes.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. See Notes.
Routes of Exposure
The substance can be absorbed into the body through the skin and by ingestion. Serious local effects by all routes of exposure.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0899
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Rats inhaling saturated HPA vapor generated at room temperature for 7 to 8 hours survived, but those exposed for 4 hours at approximately 650 ppm HPA vapor (generated at 100 °C) died either during exposure or within 1 hour after cessation of exposure. Marked signs of eye, nasal, and respiratory irritation were noted during the exposure period. | Instillation of 0.1 mL in rabbit eye produced prompt
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Expert Verdict
Expert safety assessment and concern-level summary for 2-Hydroxypropyl Acrylate.
Regulatory Flags
potential-allergen
Known Synonyms
beta-Hydroxypropyl acrylate
1,2-Propanediol, 1-acrylate
2-Propenoic acid, 2-hydroxypropyl ester
Acrylic acid, 2-hydroxypropyl ester
β-Hydroxypropyl acrylate
2-Hydroxy-2-methylethyl acrylate
BRN 1754331
EINECS 213-663-8
Propylene glycol monoacrylate
UNII-F17T4R74K6
Light Ester HOP-A
Kayarad HPA
HOP-A
Light Ester HOP-A(N)
HPA
2HPA
Light Acrylate HO-P
Chemical Function
Film former
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184912
Frequently Asked Questions
Is 2-Hydroxypropyl Acrylate allowed in the EU?
2-Hydroxypropyl Acrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hydroxypropyl Acrylate do in cosmetics?
2-Hydroxypropyl Acrylate functions as: Film forming for nail products and adhesives. It is classified as a cosmetic ingredient in our database. CAS number: 999-61-1.
Is 2-Hydroxypropyl Acrylate classified as hazardous under GHS?
2-Hydroxypropyl Acrylate carries a GHS signal word of "DANGER". Hazard statements: Combustible liquid Toxic if swallowed Fatal in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause damage to respiratory tract if inhaled May be harmful if swallowed and enters airways Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is 2-Hydroxypropyl Acrylate used outside cosmetics?
2-Hydroxypropyl Acrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Hydroxypropyl Acrylate have different safety status in cosmetics vs industrial chemicals?
2-Hydroxypropyl Acrylate is classified GHS Danger (H301, H311, H314, H317, H331, H302, H310, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-Hydroxypropyl Acrylate compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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