NOAEL Data Cosmetic Ingredient

2-Hydroxypropyl acrylate

Also known as: beta-Hydroxypropyl acrylate, 1,2-Propanediol, 1-acrylate, 2-Propenoic acid, 2-hydroxypropyl ester, Acrylic acid, 2-hydroxypropyl ester, β-Hydroxypropyl acrylate (+12 more)

CAS 999-61-1

2-Hydroxypropyl acrylate (CAS 999-61-1) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC, OSHA.

View cosmetic safety profile for 2-Hydroxypropyl Acrylate →

Cross-Vertical Regulatory Divergence

2-Hydroxypropyl acrylate is classified GHS Danger (H301, H311, H314, H317, H331, H302, H310, H318) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

2-Hydroxypropyl acrylate

CAS Number

999-61-1

DTXSID

DTXSID0022143

Molecular Formula

C6H10O3

InChI Key

GWZMWHWAWHPNHN-UHFFFAOYSA-N

Monoisotopic Mass

130.062994

Synonyms

beta-Hydroxypropyl acrylate1,2-Propanediol, 1-acrylate2-Propenoic acid, 2-hydroxypropyl esterAcrylic acid, 2-hydroxypropyl esterβ-Hydroxypropyl acrylate2-Hydroxy-2-methylethyl acrylateBRN 1754331EINECS 213-663-8Propylene glycol monoacrylateUNII-F17T4R74K6Light Ester HOP-AKayarad HPA

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Combustible liquid Toxic if swallowed Fatal in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause damage to respiratory tract if inhaled May be harmful if swallowed and enters airways Toxic to aquatic life
Short-term Effects	The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. See Notes.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. See Notes.
Routes of Exposure	The substance can be absorbed into the body through the skin and by ingestion. Serious local effects by all routes of exposure.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	TWA	0.5 ppm (3 mg/m³)	0.5	3	Y
ACGIH	TWA	0.5 ppm [1997]	0.5	-	Y
CAL/OSHA	TWA	0.5 ppm (3 mg/m³)	0.5	3	Y

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Film former

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
F17T4R74K6	UNII	FDA UNII substance identifier	-	-	openFDA substances
F17T4R74K6	UNII	FDA UNII substance identifier	-	-	openFDA substances
F17T4R74K6	UNII	FDA UNII substance identifier	-	-	openFDA substances
F17T4R74K6	UNII	FDA UNII substance identifier	-	-	openFDA substances
=250	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral

Showing 5 of 5 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3184912

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Hydroxypropyl acrylate?

2-Hydroxypropyl acrylate has 5 NOAEL studies in the database. The lowest reported value is F17T4R74K6 UNII. Source: openFDA substances.

What are the occupational exposure limits for 2-Hydroxypropyl acrylate?

Occupational exposure limits for 2-Hydroxypropyl acrylate are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Hydroxypropyl acrylate used in cosmetics?

Yes, 2-Hydroxypropyl acrylate is also indexed as a cosmetic ingredient under the name 2-Hydroxypropyl Acrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Hydroxypropyl acrylate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Hydroxypropyl acrylate have different safety status in cosmetics vs industrial chemicals?

2-Hydroxypropyl acrylate is classified GHS Danger (H301, H311, H314, H317, H331, H302, H310, H318) in the chemicals database but is allowed in EU cosmetics.

Is 2-Hydroxypropyl acrylate used outside industrial chemicals?

2-Hydroxypropyl acrylate also appears in cosmetics, pharmaceutical databases.